* Sprites are composed of [layers & frames](https://www.aseprite.org/docs/timeline/) as separated concepts.
* Support for [color profiles](https://www.aseprite.org/docs/color-profile/) and different [color modes](https://www.aseprite.org/docs/color-mode/): RGBA, Indexed (palettes up to 256 colors), Grayscale.
* [Animation facilities](https://www.aseprite.org/docs/animation/), with real-time [preview](https://www.aseprite.org/docs/preview-window/) and [onion skinning](https://www.aseprite.org/docs/onion-skinning/).
* [Layer groups](https://imgur.com/x3OKkGj) for organizing your work, and [reference layers](https://twitter.com/aseprite/status/806889204601016325) for rotoscoping.
* Pixel-art specific tools like [Pixel Perfect freehand mode](https://imgur.com/0fdlNau), [Shading ink](https://www.aseprite.org/docs/shading/), [Custom Brushes](https://twitter.com/aseprite/status/1196883990080344067), [Outlines](https://twitter.com/aseprite/status/1126548469865431041), [Wide Pixels](https://imgur.com/1yZKUcs), etc.
* Other special drawing tools like [Pressure sensitivity](https://twitter.com/aseprite/status/1253770784708886533), [Symmetry Tool](https://twitter.com/aseprite/status/659709226747625472), [Stroke and Fill](https://imgur.com/7JZQ81o) selection, [Gradients](https://twitter.com/aseprite/status/1126549217856622597).
* [Tiled mode](https://twitter.com/pixel__toast/status/1132079817736695808) useful to draw patterns and textures.
* [Reopen closed files](https://twitter.com/aseprite/status/1202641475256881153) and [recover data](https://www.aseprite.org/docs/data-recovery/) in case of crash.
* [ENDESGA Studios](https://twitter.com/ENDESGA), [EDG16 and EDG32](https://forums.tigsource.com/index.php?topic=46126.msg1279124#msg1279124), and [other palettes](https://twitter.com/ENDESGA/status/865812366931353600).
* [Adigun A. Polack](https://twitter.com/adigunpolack), [AAP-64](http://pixeljoint.com/pixelart/119466.htm), [AAP-Splendor128](http://pixeljoint.com/pixelart/120714.htm), [SimpleJPC-16](http://pixeljoint.com/pixelart/119844.htm), and [AAP-Micro12](http://pixeljoint.com/pixelart/121151.htm) palette.
* [Pixel perfect drawing algorithm](https://deepnight.net/blog/tools/pixel-perfect-drawing/) by [Sébastien Bénard](https://twitter.com/deepnightfr) and [Carduus](https://twitter.com/CarduusHimself/status/420554200737935361).