diff --git a/rpcs3/Emu/Cell/lv2/sys_event.cpp b/rpcs3/Emu/Cell/lv2/sys_event.cpp
index 26d9ffd590..def5c433d2 100644
--- a/rpcs3/Emu/Cell/lv2/sys_event.cpp
+++ b/rpcs3/Emu/Cell/lv2/sys_event.cpp
@@ -521,6 +521,12 @@ error_code sys_event_queue_receive(ppu_thread& ppu, u32 equeue_id, vm::ptr<sys_e
 					continue;
 				}
 
+				if (!atomic_storage<ppu_thread*>::load(queue->pq))
+				{
+					// Waiters queue is empty, so the thread must have been signaled
+					break;
+				}
+
 				std::lock_guard lock(queue->mutex);
 
 				if (!queue->unqueue(queue->pq, &ppu))
diff --git a/rpcs3/Emu/Cell/lv2/sys_event_flag.cpp b/rpcs3/Emu/Cell/lv2/sys_event_flag.cpp
index 26f8f4468b..639e2db586 100644
--- a/rpcs3/Emu/Cell/lv2/sys_event_flag.cpp
+++ b/rpcs3/Emu/Cell/lv2/sys_event_flag.cpp
@@ -240,6 +240,12 @@ error_code sys_event_flag_wait(ppu_thread& ppu, u32 id, u64 bitptn, u32 mode, vm
 					continue;
 				}
 
+				if (!atomic_storage<ppu_thread*>::load(flag->sq))
+				{
+					// Waiters queue is empty, so the thread must have been signaled
+					break;
+				}
+
 				std::lock_guard lock(flag->mutex);
 
 				if (!flag->unqueue(flag->sq, &ppu))
diff --git a/rpcs3/Emu/Cell/lv2/sys_lwmutex.cpp b/rpcs3/Emu/Cell/lv2/sys_lwmutex.cpp
index cfe5b7f933..1180edbbb2 100644
--- a/rpcs3/Emu/Cell/lv2/sys_lwmutex.cpp
+++ b/rpcs3/Emu/Cell/lv2/sys_lwmutex.cpp
@@ -234,6 +234,12 @@ error_code _sys_lwmutex_lock(ppu_thread& ppu, u32 lwmutex_id, u64 timeout)
 					continue;
 				}
 
+				if (!mutex->load_sq())
+				{
+					// Sleep queue is empty, so the thread must have been signaled
+					break;
+				}
+
 				std::lock_guard lock(mutex->mutex);
 
 				bool success = false;
diff --git a/rpcs3/Emu/Cell/lv2/sys_mutex.cpp b/rpcs3/Emu/Cell/lv2/sys_mutex.cpp
index 42365fe9cc..fe9232724d 100644
--- a/rpcs3/Emu/Cell/lv2/sys_mutex.cpp
+++ b/rpcs3/Emu/Cell/lv2/sys_mutex.cpp
@@ -255,6 +255,12 @@ error_code sys_mutex_lock(ppu_thread& ppu, u32 mutex_id, u64 timeout)
 					continue;
 				}
 
+				if (!atomic_storage<ppu_thread*>::load(mutex->control.raw().sq))
+				{
+					// Waiters queue is empty, so the thread must have been signaled
+					break;
+				}
+
 				std::lock_guard lock(mutex->mutex);
 
 				bool success = false;
diff --git a/rpcs3/Emu/Cell/lv2/sys_rwlock.cpp b/rpcs3/Emu/Cell/lv2/sys_rwlock.cpp
index 3a75aea91e..7736c6d958 100644
--- a/rpcs3/Emu/Cell/lv2/sys_rwlock.cpp
+++ b/rpcs3/Emu/Cell/lv2/sys_rwlock.cpp
@@ -196,6 +196,12 @@ error_code sys_rwlock_rlock(ppu_thread& ppu, u32 rw_lock_id, u64 timeout)
 					continue;
 				}
 
+				if (!atomic_storage<ppu_thread*>::load(rwlock->rq))
+				{
+					// Waiters queue is empty, so the thread must have been signaled
+					break;
+				}
+
 				std::lock_guard lock(rwlock->mutex);
 
 				if (!rwlock->unqueue(rwlock->rq, &ppu))