diff --git a/rpcs3/Input/keyboard_pad_handler.cpp b/rpcs3/Input/keyboard_pad_handler.cpp
index 926c355f38..7bb6f80b92 100644
--- a/rpcs3/Input/keyboard_pad_handler.cpp
+++ b/rpcs3/Input/keyboard_pad_handler.cpp
@@ -435,34 +435,7 @@ void keyboard_pad_handler::processKeyEvent(QKeyEvent* event, bool pressed)
 		}
 	};
 
-	// We need to ignore keys when using rpcs3 keyboard shortcuts
-	// NOTE: needs to be updated with gs_frame::keyPressEvent
-	switch (event->key())
-	{
-	case Qt::Key_Escape:
-	case Qt::Key_F11:
-	case Qt::Key_F12:
-		break;
-	case Qt::Key_L:
-		if (event->modifiers() != Qt::AltModifier && event->modifiers() != Qt::ControlModifier)
-			handle_key();
-		break;
-	case Qt::Key_Return:
-		if (event->modifiers() != Qt::AltModifier)
-			handle_key();
-		break;
-	case Qt::Key_P:
-	case Qt::Key_S:
-	case Qt::Key_R:
-	case Qt::Key_E:
-	case Qt::Key_0:
-		if (event->modifiers() != Qt::ControlModifier)
-			handle_key();
-		break;
-	default:
-		handle_key();
-		break;
-	}
+	handle_key();
 	event->ignore();
 }
 
diff --git a/rpcs3/rpcs3qt/gs_frame.cpp b/rpcs3/rpcs3qt/gs_frame.cpp
index b21703d2ec..ccfb3327cf 100644
--- a/rpcs3/rpcs3qt/gs_frame.cpp
+++ b/rpcs3/rpcs3qt/gs_frame.cpp
@@ -123,9 +123,8 @@ gs_frame::gs_frame(QScreen* screen, const QRect& geometry, const QIcon& appIcon,
 		create();
 	}
 
-	// TODO: enable in Qt6
-	//m_shortcut_handler = new shortcut_handler(gui::shortcuts::shortcut_handler_id::game_window, this, m_gui_settings);
-	//connect(m_shortcut_handler, &shortcut_handler::shortcut_activated, this, &gs_frame::handle_shortcut);
+	m_shortcut_handler = new shortcut_handler(gui::shortcuts::shortcut_handler_id::game_window, this, m_gui_settings);
+	connect(m_shortcut_handler, &shortcut_handler::shortcut_activated, this, &gs_frame::handle_shortcut);
 
 	// Change cursor when in fullscreen.
 	connect(this, &QWindow::visibilityChanged, this, [this](QWindow::Visibility visibility)
@@ -178,6 +177,14 @@ void gs_frame::load_gui_settings()
 	m_hide_mouse_idletime = m_gui_settings->GetValue(gui::gs_hideMouseIdleTime).toUInt();
 }
 
+void gs_frame::update_shortcuts()
+{
+	if (m_shortcut_handler)
+	{
+		m_shortcut_handler->update();
+	}
+}
+
 void gs_frame::paintEvent(QPaintEvent *event)
 {
 	Q_UNUSED(event)
@@ -226,94 +233,6 @@ void gs_frame::showEvent(QShowEvent *event)
 	QWindow::showEvent(event);
 }
 
-// TODO: remove when shortcuts are properly hooked up (also check keyboard_pad_handler::processKeyEvent)
-void gs_frame::keyPressEvent(QKeyEvent *keyEvent)
-{
-	if (keyEvent->isAutoRepeat())
-	{
-		keyEvent->ignore();
-		return;
-	}
-
-	// NOTE: needs to be updated with keyboard_pad_handler::processKeyEvent
-
-	switch (keyEvent->key())
-	{
-	case Qt::Key_L:
-	{
-		if (keyEvent->modifiers() == Qt::AltModifier)
-		{
-			handle_shortcut(gui::shortcuts::shortcut::gw_log_mark, {});
-			break;
-		}
-		else if (keyEvent->modifiers() == Qt::ControlModifier)
-		{
-			handle_shortcut(gui::shortcuts::shortcut::gw_mouse_lock, {});
-			break;
-		}
-		break;
-	}
-	case Qt::Key_Return:
-	{
-		if (keyEvent->modifiers() == Qt::AltModifier)
-			handle_shortcut(gui::shortcuts::shortcut::gw_toggle_fullscreen, {});
-		break;
-	}
-	case Qt::Key_Escape:
-	{
-		handle_shortcut(gui::shortcuts::shortcut::gw_exit_fullscreen, {});
-		break;
-	}
-	case Qt::Key_P:
-	{
-		if (keyEvent->modifiers() == Qt::ControlModifier)
-			handle_shortcut(gui::shortcuts::shortcut::gw_pause_play, {});
-		break;
-	}
-	case Qt::Key_S:
-	{
-		if (keyEvent->modifiers() == Qt::ControlModifier)
-			handle_shortcut(gui::shortcuts::shortcut::gw_savestate, {});
-		break;
-	}
-	case Qt::Key_R:
-	{
-		if (keyEvent->modifiers() == Qt::ControlModifier)
-			handle_shortcut(gui::shortcuts::shortcut::gw_restart, {});
-		break;
-	}
-	case Qt::Key_C:
-	{
-		if (keyEvent->modifiers() == Qt::AltModifier)
-			handle_shortcut(gui::shortcuts::shortcut::gw_rsx_capture, {});
-		break;
-	}
-	case Qt::Key_F10:
-	{
-		if (keyEvent->modifiers() == Qt::ControlModifier)
-			handle_shortcut(gui::shortcuts::shortcut::gw_frame_limit, {});
-		break;
-	}
-	case Qt::Key_F11:
-	{
-		if (keyEvent->modifiers() == Qt::ControlModifier)
-			handle_shortcut(gui::shortcuts::shortcut::gw_toggle_mouse_and_keyboard, {});
-		else
-			handle_shortcut(gui::shortcuts::shortcut::gw_toggle_recording, {});
-		break;
-	}
-	case Qt::Key_F12:
-	{
-		handle_shortcut(gui::shortcuts::shortcut::gw_screenshot, {});
-		break;
-	}
-	default:
-	{
-		break;
-	}
-	}
-}
-
 void gs_frame::handle_shortcut(gui::shortcuts::shortcut shortcut_key, const QKeySequence& key_sequence)
 {
 	gui_log.notice("Game window registered shortcut: %s (%s)", shortcut_key, key_sequence.toString());
diff --git a/rpcs3/rpcs3qt/gs_frame.h b/rpcs3/rpcs3qt/gs_frame.h
index 95d358105e..97a777360c 100644
--- a/rpcs3/rpcs3qt/gs_frame.h
+++ b/rpcs3/rpcs3qt/gs_frame.h
@@ -24,6 +24,8 @@ private:
 	// taskbar progress
 	std::unique_ptr<progress_indicator> m_progress_indicator;
 
+	shortcut_handler* m_shortcut_handler = nullptr;
+
 	QRect m_initial_geometry;
 
 	std::shared_ptr<gui_settings> m_gui_settings;
@@ -55,6 +57,8 @@ public:
 	void delete_context(draw_context_t context) override;
 	void toggle_fullscreen() override;
 
+	void update_shortcuts();
+
 	// taskbar progress
 	void progress_reset(bool reset_limit = false);
 	void progress_set_value(int value);
@@ -75,8 +79,6 @@ protected:
 	void paintEvent(QPaintEvent *event) override;
 	void showEvent(QShowEvent *event) override;
 
-	void keyPressEvent(QKeyEvent *keyEvent) override;
-
 	void close() override;
 
 	bool shown() override;
diff --git a/rpcs3/rpcs3qt/gui_application.cpp b/rpcs3/rpcs3qt/gui_application.cpp
index 0b1cce3e37..54742e2404 100644
--- a/rpcs3/rpcs3qt/gui_application.cpp
+++ b/rpcs3/rpcs3qt/gui_application.cpp
@@ -309,6 +309,7 @@ void gui_application::InitializeConnects()
 		connect(m_main_window, &main_window::RequestLanguageChange, this, &gui_application::LoadLanguage);
 		connect(m_main_window, &main_window::RequestGlobalStylesheetChange, this, &gui_application::OnChangeStyleSheetRequest);
 		connect(m_main_window, &main_window::NotifyEmuSettingsChange, this, [this](){ OnEmuSettingsChange(); });
+		connect(m_main_window, &main_window::NotifyShortcutHandlers, this, &gui_application::OnShortcutChange);
 
 		connect(this, &gui_application::OnEmulatorRun, m_main_window, &main_window::OnEmuRun);
 		connect(this, &gui_application::OnEmulatorStop, m_main_window, &main_window::OnEmuStop);
@@ -1031,6 +1032,14 @@ void gui_application::OnChangeStyleSheetRequest()
 	}
 }
 
+void gui_application::OnShortcutChange()
+{
+	if (m_game_window)
+	{
+		static_cast<gs_frame*>(m_game_window)->update_shortcuts();
+	}
+}
+
 /**
  * Using connects avoids timers being unable to be used in a non-qt thread. So, even if this looks stupid to just call func, it's succinct.
  */
diff --git a/rpcs3/rpcs3qt/gui_application.h b/rpcs3/rpcs3qt/gui_application.h
index 87b86d9bc3..d37836e04a 100644
--- a/rpcs3/rpcs3qt/gui_application.h
+++ b/rpcs3/rpcs3qt/gui_application.h
@@ -121,6 +121,7 @@ private:
 
 private Q_SLOTS:
 	void OnChangeStyleSheetRequest();
+	void OnShortcutChange();
 	void OnAppStateChanged(Qt::ApplicationState state);
 
 Q_SIGNALS:
diff --git a/rpcs3/rpcs3qt/main_window.cpp b/rpcs3/rpcs3qt/main_window.cpp
index e18a5efacf..e13603e72f 100644
--- a/rpcs3/rpcs3qt/main_window.cpp
+++ b/rpcs3/rpcs3qt/main_window.cpp
@@ -2762,7 +2762,11 @@ void main_window::CreateConnects()
 	connect(ui->confShortcutsAct, &QAction::triggered, [this]()
 	{
 		shortcut_dialog dlg(m_gui_settings, this);
-		connect(&dlg, &shortcut_dialog::saved, m_shortcut_handler, &shortcut_handler::update);
+		connect(&dlg, &shortcut_dialog::saved, this, [this]()
+		{
+			m_shortcut_handler->update();
+			NotifyShortcutHandlers();
+		});
 		dlg.exec();
 	});
 
diff --git a/rpcs3/rpcs3qt/main_window.h b/rpcs3/rpcs3qt/main_window.h
index 7bad86b653..de6ad8ab0d 100644
--- a/rpcs3/rpcs3qt/main_window.h
+++ b/rpcs3/rpcs3qt/main_window.h
@@ -98,6 +98,7 @@ Q_SIGNALS:
 	void RequestDialogRepaint();
 	void NotifyEmuSettingsChange();
 	void NotifyWindowCloseEvent(bool closed);
+	void NotifyShortcutHandlers();
 
 public Q_SLOTS:
 	void OnEmuStop();
diff --git a/rpcs3/rpcs3qt/shortcut_dialog.ui b/rpcs3/rpcs3qt/shortcut_dialog.ui
index 84b2672722..efafa998a2 100644
--- a/rpcs3/rpcs3qt/shortcut_dialog.ui
+++ b/rpcs3/rpcs3qt/shortcut_dialog.ui
@@ -43,9 +43,6 @@
      </item>
      <item>
       <widget class="QGroupBox" name="game_window_group_box">
-       <property name="enabled">
-        <bool>false</bool>
-       </property>
        <property name="title">
         <string>Game Window Shortcuts</string>
        </property>
diff --git a/rpcs3/rpcs3qt/shortcut_handler.cpp b/rpcs3/rpcs3qt/shortcut_handler.cpp
index 91f67df3e4..8ebefaa899 100644
--- a/rpcs3/rpcs3qt/shortcut_handler.cpp
+++ b/rpcs3/rpcs3qt/shortcut_handler.cpp
@@ -4,7 +4,7 @@
 
 LOG_CHANNEL(shortcut_log, "Shortcuts");
 
-shortcut_handler::shortcut_handler(gui::shortcuts::shortcut_handler_id handler_id, QWidget* parent, const std::shared_ptr<gui_settings>& gui_settings)
+shortcut_handler::shortcut_handler(gui::shortcuts::shortcut_handler_id handler_id, QObject* parent, const std::shared_ptr<gui_settings>& gui_settings)
 	: QObject(parent), m_handler_id(handler_id), m_gui_settings(gui_settings)
 {
 	// Initialize shortcuts
diff --git a/rpcs3/rpcs3qt/shortcut_handler.h b/rpcs3/rpcs3qt/shortcut_handler.h
index c0f6597dce..3f667a832d 100644
--- a/rpcs3/rpcs3qt/shortcut_handler.h
+++ b/rpcs3/rpcs3qt/shortcut_handler.h
@@ -13,7 +13,7 @@ class shortcut_handler : public QObject
 	Q_OBJECT
 
 public:
-	shortcut_handler(gui::shortcuts::shortcut_handler_id handler_id, QWidget* parent, const std::shared_ptr<gui_settings>& gui_settings);
+	shortcut_handler(gui::shortcuts::shortcut_handler_id handler_id, QObject* parent, const std::shared_ptr<gui_settings>& gui_settings);
 
 Q_SIGNALS:
 	void shortcut_activated(gui::shortcuts::shortcut shortcut_key, const QKeySequence& key_sequence);
diff --git a/rpcs3/rpcs3qt/shortcut_settings.cpp b/rpcs3/rpcs3qt/shortcut_settings.cpp
index 5a6c9e3b16..d7ed07eafd 100644
--- a/rpcs3/rpcs3qt/shortcut_settings.cpp
+++ b/rpcs3/rpcs3qt/shortcut_settings.cpp
@@ -78,6 +78,9 @@ gui_save shortcut_settings::get_shortcut_gui_save(const QString& shortcut_name)
 
 QKeySequence shortcut_settings::get_key_sequence(const shortcut_info& entry, const std::shared_ptr<gui_settings>& gui_settings)
 {
+	if (!gui_settings)
+		return {};
+
 	const QString saved_value = gui_settings->GetValue(get_shortcut_gui_save(entry.name)).toString();
 
 	QKeySequence key_sequence = QKeySequence::fromString(saved_value);