diff --git a/Utilities/bin_patch.cpp b/Utilities/bin_patch.cpp
index 16d317c0f3..113ce1ccc4 100644
--- a/Utilities/bin_patch.cpp
+++ b/Utilities/bin_patch.cpp
@@ -551,6 +551,9 @@ std::size_t patch_engine::apply_patch(const std::string& name, u8* dst, u32 file
 	const auto serial = Emu.GetTitleID();
 	const auto app_version = Emu.GetAppVersion();
 
+	// Only one patch per patch group is allowed
+	std::set<std::string> applied_groups;
+
 	// Apply modifications sequentially
 	for (const auto& [description, patch] : container.patch_info_map)
 	{
@@ -601,6 +604,16 @@ std::size_t patch_engine::apply_patch(const std::string& name, u8* dst, u32 file
 			continue;
 		}
 
+		if (!patch.patch_group.empty())
+		{
+			if (applied_groups.contains(patch.patch_group))
+			{
+				continue;
+			}
+
+			applied_groups.insert(patch.patch_group);
+		}
+
 		size_t applied = 0;
 
 		for (const auto& p : patch.data_list)