diff --git a/configs/config-ccm-psk-dtls1_2.h b/configs/config-ccm-psk-dtls1_2.h
index 19e09d957f..be785b7aec 100644
--- a/configs/config-ccm-psk-dtls1_2.h
+++ b/configs/config-ccm-psk-dtls1_2.h
@@ -23,19 +23,20 @@
  * See README.txt for usage instructions.
  */
 
+#define MBEDTLS_PSA_CRYPTO_CONFIG_FILE "../configs/crypto-config-ccm-psk-tls1_2.h"
+
+#define MBEDTLS_PSA_CRYPTO_C
+#define MBEDTLS_PSA_CRYPTO_CONFIG
+#define MBEDTLS_USE_PSA_CRYPTO
+
 /* System support */
 //#define MBEDTLS_HAVE_TIME /* Optionally used in Hello messages */
 /* Other MBEDTLS_HAVE_XXX flags irrelevant for this configuration */
 
 /* Mbed TLS modules */
-#define MBEDTLS_AES_C
-#define MBEDTLS_CCM_C
-#define MBEDTLS_CIPHER_C
 #define MBEDTLS_CTR_DRBG_C
 #define MBEDTLS_ENTROPY_C
-#define MBEDTLS_MD_C
 #define MBEDTLS_NET_C
-#define MBEDTLS_SHA256_C
 #define MBEDTLS_SSL_CLI_C
 #define MBEDTLS_SSL_COOKIE_C
 #define MBEDTLS_SSL_SRV_C
@@ -81,11 +82,6 @@
  */
 #define MBEDTLS_ENTROPY_MAX_SOURCES 2
 
-/* These defines are present so that the config modifying scripts can enable
- * them during tests/scripts/test-ref-configs.pl */
-//#define MBEDTLS_USE_PSA_CRYPTO
-//#define MBEDTLS_PSA_CRYPTO_C
-
 /* Error messages and TLS debugging traces
  * (huge code size increase, needed for tests/ssl-opt.sh) */
 //#define MBEDTLS_DEBUG_C
diff --git a/configs/config-ccm-psk-tls1_2.h b/configs/config-ccm-psk-tls1_2.h
index d49adfd725..d8f4f9c180 100644
--- a/configs/config-ccm-psk-tls1_2.h
+++ b/configs/config-ccm-psk-tls1_2.h
@@ -22,19 +22,20 @@
  * See README.txt for usage instructions.
  */
 
+#define MBEDTLS_PSA_CRYPTO_CONFIG_FILE "../configs/crypto-config-ccm-psk-tls1_2.h"
+
+#define MBEDTLS_PSA_CRYPTO_C
+#define MBEDTLS_PSA_CRYPTO_CONFIG
+#define MBEDTLS_USE_PSA_CRYPTO
+
 /* System support */
 //#define MBEDTLS_HAVE_TIME /* Optionally used in Hello messages */
 /* Other MBEDTLS_HAVE_XXX flags irrelevant for this configuration */
 
 /* Mbed TLS modules */
-#define MBEDTLS_AES_C
-#define MBEDTLS_CCM_C
-#define MBEDTLS_CIPHER_C
 #define MBEDTLS_CTR_DRBG_C
 #define MBEDTLS_ENTROPY_C
-#define MBEDTLS_MD_C
 #define MBEDTLS_NET_C
-#define MBEDTLS_SHA256_C
 #define MBEDTLS_SSL_CLI_C
 #define MBEDTLS_SSL_SRV_C
 #define MBEDTLS_SSL_TLS_C
@@ -72,11 +73,6 @@
  */
 #define MBEDTLS_ENTROPY_MAX_SOURCES 2
 
-/* These defines are present so that the config modifying scripts can enable
- * them during tests/scripts/test-ref-configs.pl */
-//#define MBEDTLS_USE_PSA_CRYPTO
-//#define MBEDTLS_PSA_CRYPTO_C
-
 /* Error messages and TLS debugging traces
  * (huge code size increase, needed for tests/ssl-opt.sh) */
 //#define MBEDTLS_DEBUG_C
diff --git a/configs/config-suite-b.h b/configs/config-suite-b.h
index 9bba6e6cbd..cdea16e25a 100644
--- a/configs/config-suite-b.h
+++ b/configs/config-suite-b.h
@@ -21,36 +21,29 @@
  * See README.txt for usage instructions.
  */
 
+#define MBEDTLS_PSA_CRYPTO_CONFIG_FILE "../configs/crypto-config-suite-b.h"
+
+#define MBEDTLS_PSA_CRYPTO_C
+#define MBEDTLS_PSA_CRYPTO_CONFIG
+#define MBEDTLS_USE_PSA_CRYPTO
+
 /* System support */
 #define MBEDTLS_HAVE_ASM
 #define MBEDTLS_HAVE_TIME
 
 /* Mbed TLS feature support */
-#define MBEDTLS_ECP_DP_SECP256R1_ENABLED
-#define MBEDTLS_ECP_DP_SECP384R1_ENABLED
 #define MBEDTLS_KEY_EXCHANGE_ECDHE_ECDSA_ENABLED
 #define MBEDTLS_SSL_PROTO_TLS1_2
 
 /* Mbed TLS modules */
-#define MBEDTLS_AES_C
 #define MBEDTLS_ASN1_PARSE_C
 #define MBEDTLS_ASN1_WRITE_C
-#define MBEDTLS_BIGNUM_C
-#define MBEDTLS_CIPHER_C
 #define MBEDTLS_CTR_DRBG_C
-#define MBEDTLS_ECDH_C
-#define MBEDTLS_ECDSA_C
-#define MBEDTLS_ECP_C
 #define MBEDTLS_ENTROPY_C
-#define MBEDTLS_GCM_C
-#define MBEDTLS_MD_C
 #define MBEDTLS_NET_C
 #define MBEDTLS_OID_C
 #define MBEDTLS_PK_C
 #define MBEDTLS_PK_PARSE_C
-#define MBEDTLS_SHA256_C
-#define MBEDTLS_SHA384_C
-#define MBEDTLS_SHA512_C
 #define MBEDTLS_SSL_CLI_C
 #define MBEDTLS_SSL_SRV_C
 #define MBEDTLS_SSL_TLS_C
@@ -95,11 +88,6 @@
 #define MBEDTLS_SSL_IN_CONTENT_LEN             1024
 #define MBEDTLS_SSL_OUT_CONTENT_LEN             1024
 
-/* These defines are present so that the config modifying scripts can enable
- * them during tests/scripts/test-ref-configs.pl */
-//#define MBEDTLS_USE_PSA_CRYPTO
-//#define MBEDTLS_PSA_CRYPTO_C
-
 /* Error messages and TLS debugging traces
  * (huge code size increase, needed for tests/ssl-opt.sh) */
 //#define MBEDTLS_DEBUG_C
diff --git a/configs/config-symmetric-only.h b/configs/config-symmetric-only.h
index 512dd7616c..13e4d26677 100644
--- a/configs/config-symmetric-only.h
+++ b/configs/config-symmetric-only.h
@@ -8,70 +8,43 @@
  *  SPDX-License-Identifier: Apache-2.0 OR GPL-2.0-or-later
  */
 
+#define MBEDTLS_PSA_CRYPTO_CONFIG_FILE "../configs/crypto-config-symmetric-only.h"
+
+#define MBEDTLS_PSA_CRYPTO_C
+#define MBEDTLS_PSA_CRYPTO_CONFIG
+#define MBEDTLS_USE_PSA_CRYPTO
+
 /* System support */
 //#define MBEDTLS_HAVE_ASM
 #define MBEDTLS_HAVE_TIME
 #define MBEDTLS_HAVE_TIME_DATE
 
 /* Mbed TLS feature support */
-#define MBEDTLS_CIPHER_MODE_CBC
-#define MBEDTLS_CIPHER_MODE_CFB
-#define MBEDTLS_CIPHER_MODE_CTR
-#define MBEDTLS_CIPHER_MODE_OFB
-#define MBEDTLS_CIPHER_MODE_XTS
-#define MBEDTLS_CIPHER_PADDING_PKCS7
-#define MBEDTLS_CIPHER_PADDING_ONE_AND_ZEROS
-#define MBEDTLS_CIPHER_PADDING_ZEROS_AND_LEN
-#define MBEDTLS_CIPHER_PADDING_ZEROS
 #define MBEDTLS_ERROR_STRERROR_DUMMY
 #define MBEDTLS_FS_IO
 #define MBEDTLS_ENTROPY_NV_SEED
 #define MBEDTLS_SELF_TEST
-#define MBEDTLS_USE_PSA_CRYPTO
 #define MBEDTLS_VERSION_FEATURES
 
 /* Mbed TLS modules */
-#define MBEDTLS_AES_C
 #define MBEDTLS_ASN1_PARSE_C
 #define MBEDTLS_ASN1_WRITE_C
 #define MBEDTLS_BASE64_C
-#define MBEDTLS_CAMELLIA_C
-#define MBEDTLS_ARIA_C
-#define MBEDTLS_CCM_C
-#define MBEDTLS_CHACHA20_C
-#define MBEDTLS_CHACHAPOLY_C
-#define MBEDTLS_CIPHER_C
-#define MBEDTLS_CMAC_C
 #define MBEDTLS_CTR_DRBG_C
-#define MBEDTLS_DES_C
 #define MBEDTLS_ENTROPY_C
 #define MBEDTLS_ERROR_C
-#define MBEDTLS_GCM_C
-#define MBEDTLS_HKDF_C
 #define MBEDTLS_HMAC_DRBG_C
 #define MBEDTLS_NIST_KW_C
-#define MBEDTLS_MD_C
-#define MBEDTLS_MD5_C
 #define MBEDTLS_OID_C
 #define MBEDTLS_PEM_PARSE_C
 #define MBEDTLS_PEM_WRITE_C
 #define MBEDTLS_PKCS5_C
 #define MBEDTLS_PKCS12_C
 #define MBEDTLS_PLATFORM_C
-#define MBEDTLS_POLY1305_C
-#define MBEDTLS_PSA_CRYPTO_C
 #define MBEDTLS_PSA_CRYPTO_SE_C
 #define MBEDTLS_PSA_CRYPTO_STORAGE_C
 #define MBEDTLS_PSA_ITS_FILE_C
-#define MBEDTLS_RIPEMD160_C
-#define MBEDTLS_SHA1_C
-/* The library does not currently support enabling SHA-224 without SHA-256.
- * A future version of the library will have this option disabled
- * by default. */
-#define MBEDTLS_SHA224_C
-#define MBEDTLS_SHA256_C
-#define MBEDTLS_SHA384_C
-#define MBEDTLS_SHA512_C
+
 //#define MBEDTLS_THREADING_C
 #define MBEDTLS_TIMING_C
 #define MBEDTLS_VERSION_C
diff --git a/configs/config-thread.h b/configs/config-thread.h
index 2f81f90078..160aded92c 100644
--- a/configs/config-thread.h
+++ b/configs/config-thread.h
@@ -17,15 +17,21 @@
  * - no X.509
  * - support for experimental EC J-PAKE key exchange
  *
+ * To be used in conjunction with configs/crypto-config-thread.h.
  * See README.txt for usage instructions.
  */
 
+#define MBEDTLS_PSA_CRYPTO_CONFIG_FILE "../configs/crypto-config-thread.h"
+
+#define MBEDTLS_PSA_CRYPTO_C
+#define MBEDTLS_PSA_CRYPTO_CONFIG
+#define MBEDTLS_USE_PSA_CRYPTO
+
 /* System support */
 #define MBEDTLS_HAVE_ASM
 
 /* Mbed TLS feature support */
 #define MBEDTLS_AES_ROM_TABLES
-#define MBEDTLS_ECP_DP_SECP256R1_ENABLED
 #define MBEDTLS_ECP_NIST_OPTIM
 #define MBEDTLS_KEY_EXCHANGE_ECJPAKE_ENABLED
 #define MBEDTLS_SSL_MAX_FRAGMENT_LENGTH
@@ -35,23 +41,15 @@
 #define MBEDTLS_SSL_DTLS_HELLO_VERIFY
 
 /* Mbed TLS modules */
-#define MBEDTLS_AES_C
 #define MBEDTLS_ASN1_PARSE_C
 #define MBEDTLS_ASN1_WRITE_C
-#define MBEDTLS_BIGNUM_C
-#define MBEDTLS_CCM_C
-#define MBEDTLS_CIPHER_C
 #define MBEDTLS_CTR_DRBG_C
-#define MBEDTLS_CMAC_C
-#define MBEDTLS_ECJPAKE_C
-#define MBEDTLS_ECP_C
 #define MBEDTLS_ENTROPY_C
 #define MBEDTLS_HMAC_DRBG_C
 #define MBEDTLS_MD_C
 #define MBEDTLS_OID_C
 #define MBEDTLS_PK_C
 #define MBEDTLS_PK_PARSE_C
-#define MBEDTLS_SHA256_C
 #define MBEDTLS_SSL_COOKIE_C
 #define MBEDTLS_SSL_CLI_C
 #define MBEDTLS_SSL_SRV_C
@@ -69,8 +67,3 @@
 
 /* Save ROM and a few bytes of RAM by specifying our own ciphersuite list */
 #define MBEDTLS_SSL_CIPHERSUITES MBEDTLS_TLS_ECJPAKE_WITH_AES_128_CCM_8
-
-/* These defines are present so that the config modifying scripts can enable
- * them during tests/scripts/test-ref-configs.pl */
-//#define MBEDTLS_USE_PSA_CRYPTO
-//#define MBEDTLS_PSA_CRYPTO_C
diff --git a/configs/crypto-config-ccm-aes-sha256.h b/configs/crypto-config-ccm-aes-sha256.h
index 7f8d58768c..68a9c0a539 100644
--- a/configs/crypto-config-ccm-aes-sha256.h
+++ b/configs/crypto-config-ccm-aes-sha256.h
@@ -2,7 +2,7 @@
  * \file configs/crypto-config-ccm-aes-sha256.h
  *
  * \brief PSA crypto configuration with only symmetric cryptography: CCM-AES,
- *        SHA-256, HMAC and key derivation
+ *        SHA-256 and key derivation (uses HMAC).
  */
 /*
  *  Copyright The Mbed TLS Contributors
@@ -13,12 +13,10 @@
 #define PSA_CRYPTO_CONFIG_H
 
 #define PSA_WANT_ALG_CCM 1
-#define PSA_WANT_ALG_HMAC 1
 #define PSA_WANT_ALG_SHA_256 1
 #define PSA_WANT_ALG_TLS12_PRF 1
 #define PSA_WANT_ALG_TLS12_PSK_TO_MS 1
 #define PSA_WANT_KEY_TYPE_DERIVE 1
-#define PSA_WANT_KEY_TYPE_HMAC 1
 #define PSA_WANT_KEY_TYPE_AES 1
 #define PSA_WANT_KEY_TYPE_RAW_DATA 1
 
diff --git a/configs/crypto-config-ccm-psk-tls1_2.h b/configs/crypto-config-ccm-psk-tls1_2.h
new file mode 100644
index 0000000000..f4928e2ee0
--- /dev/null
+++ b/configs/crypto-config-ccm-psk-tls1_2.h
@@ -0,0 +1,25 @@
+/**
+ * \file crypto-config-ccm-psk-tls1_2.h
+ *
+ * \brief Minimal crypto configuration for TLS 1.2 with
+ * PSK and AES-CCM ciphersuites
+ */
+/*
+ *  Copyright The Mbed TLS Contributors
+ *  SPDX-License-Identifier: Apache-2.0 OR GPL-2.0-or-later
+ */
+
+/**
+ * To be used in conjunction with configs/config-ccm-psk-tls1_2.h
+ * or configs/config-ccm-psk-dtls1_2.h. */
+
+#ifndef PSA_CRYPTO_CONFIG_H
+#define PSA_CRYPTO_CONFIG_H
+
+#define PSA_WANT_ALG_CCM                        1
+#define PSA_WANT_ALG_SHA_256                    1
+#define PSA_WANT_ALG_TLS12_PRF                  1
+#define PSA_WANT_ALG_TLS12_PSK_TO_MS            1
+
+#define PSA_WANT_KEY_TYPE_AES                   1
+#endif /* PSA_CRYPTO_CONFIG_H */
diff --git a/configs/crypto-config-suite-b.h b/configs/crypto-config-suite-b.h
new file mode 100644
index 0000000000..ec209193e0
--- /dev/null
+++ b/configs/crypto-config-suite-b.h
@@ -0,0 +1,41 @@
+/**
+ * \file crypto-config-symmetric-only.h
+ *
+ * \brief \brief Minimal crypto configuration for
+ * TLS NSA Suite B Profile (RFC 6460).
+ */
+/*
+ *  Copyright The Mbed TLS Contributors
+ *  SPDX-License-Identifier: Apache-2.0 OR GPL-2.0-or-later
+ */
+
+/**
+ * Minimal crypto configuration for TLS NSA Suite B Profile (RFC 6460)
+ *
+ * Distinguishing features:
+ * - no RSA or classic DH, fully based on ECC
+ * - optimized for low RAM usage
+ *
+ * Possible improvements:
+ * - if 128-bit security is enough, disable secp384r1 and SHA-512
+ *
+ * To be used in conjunction with configs/config-suite-b.h. */
+
+#ifndef PSA_CRYPTO_CONFIG_H
+#define PSA_CRYPTO_CONFIG_H
+
+#define PSA_WANT_ALG_ECDH                        1
+#define PSA_WANT_ALG_ECDSA                       1
+#define PSA_WANT_ALG_GCM                         1
+#define PSA_WANT_ALG_SHA_256                     1
+#define PSA_WANT_ALG_SHA_384                     1
+#define PSA_WANT_ALG_SHA_512                     1
+#define PSA_WANT_ECC_SECP_R1_256                 1
+#define PSA_WANT_ECC_SECP_R1_384                 1
+#define PSA_WANT_ALG_TLS12_PRF                   1
+
+#define PSA_WANT_KEY_TYPE_AES                    1
+#define PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_BASIC     1
+#define PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_IMPORT    1
+#define PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_GENERATE  1
+#endif /* PSA_CRYPTO_CONFIG_H */
diff --git a/configs/crypto-config-symmetric-only.h b/configs/crypto-config-symmetric-only.h
new file mode 100644
index 0000000000..5d6bf85291
--- /dev/null
+++ b/configs/crypto-config-symmetric-only.h
@@ -0,0 +1,58 @@
+/**
+ * \file crypto-config-symmetric-only.h
+ *
+ * \brief Crypto configuration without any asymmetric cryptography.
+ */
+/*
+ *  Copyright The Mbed TLS Contributors
+ *  SPDX-License-Identifier: Apache-2.0 OR GPL-2.0-or-later
+ */
+
+/**
+ * To be used in conjunction with configs/config-symmetric-only.h. */
+
+#ifndef PSA_CRYPTO_CONFIG_H
+#define PSA_CRYPTO_CONFIG_H
+
+#define PSA_WANT_ALG_CBC_NO_PADDING             1
+#define PSA_WANT_ALG_CBC_PKCS7                  1
+#define PSA_WANT_ALG_CCM                        1
+#define PSA_WANT_ALG_CCM_STAR_NO_TAG            1
+#define PSA_WANT_ALG_CFB                        1
+#define PSA_WANT_ALG_CHACHA20_POLY1305          1
+#define PSA_WANT_ALG_CMAC                       1
+#define PSA_WANT_ALG_CTR                        1
+#define PSA_WANT_ALG_ECB_NO_PADDING             1
+#define PSA_WANT_ALG_GCM                        1
+#define PSA_WANT_ALG_HKDF                       1
+#define PSA_WANT_ALG_HKDF_EXTRACT               1
+#define PSA_WANT_ALG_HKDF_EXPAND                1
+#define PSA_WANT_ALG_HMAC                       1
+#define PSA_WANT_ALG_MD5                        1
+#define PSA_WANT_ALG_OFB                        1
+#define PSA_WANT_ALG_RIPEMD160                  1
+#define PSA_WANT_ALG_SHA_1                      1
+#define PSA_WANT_ALG_STREAM_CIPHER              1
+#define PSA_WANT_ALG_SHA_224                    1
+#define PSA_WANT_ALG_SHA_256                    1
+#define PSA_WANT_ALG_SHA_384                    1
+#define PSA_WANT_ALG_SHA_512                    1
+#define PSA_WANT_ALG_SHA3_224                   1
+#define PSA_WANT_ALG_SHA3_256                   1
+#define PSA_WANT_ALG_SHA3_384                   1
+#define PSA_WANT_ALG_SHA3_512                   1
+#define PSA_WANT_ALG_TLS12_ECJPAKE_TO_PMS       1
+#define PSA_WANT_ALG_TLS12_PRF                  1
+#define PSA_WANT_ALG_TLS12_PSK_TO_MS            1
+
+/* XTS is not yet supported via the PSA API in Mbed TLS. */
+//#define PSA_WANT_ALG_XTS                        1
+
+#define PSA_WANT_KEY_TYPE_AES                   1
+#define PSA_WANT_KEY_TYPE_ARIA                  1
+#define PSA_WANT_KEY_TYPE_CAMELLIA              1
+#define PSA_WANT_KEY_TYPE_CHACHA20              1
+#define PSA_WANT_KEY_TYPE_DES                   1
+#define PSA_WANT_KEY_TYPE_HMAC                  1
+
+#endif /* PSA_CRYPTO_CONFIG_H */
diff --git a/configs/crypto-config-thread.h b/configs/crypto-config-thread.h
new file mode 100644
index 0000000000..3c5fe247c3
--- /dev/null
+++ b/configs/crypto-config-thread.h
@@ -0,0 +1,47 @@
+/**
+ * \file crypto-config-thread.h
+ *
+ * \brief Minimal crypto configuration for using TLS as part of Thread
+ */
+/*
+ *  Copyright The Mbed TLS Contributors
+ *  SPDX-License-Identifier: Apache-2.0 OR GPL-2.0-or-later
+ */
+
+/**
+ * Minimal crypto configuration for using TLS as part of Thread
+ * http://threadgroup.org/
+ *
+ * Distinguishing features:
+ * - no RSA or classic DH, fully based on ECC
+ * - no X.509
+ * - support for experimental EC J-PAKE key exchange
+ * - support for PBKDF2-AES-CMAC-PRF-128 password-hashing or key-stretching
+ *   algorithm.
+ *
+ * To be used in conjunction with configs/config-thread.h.
+ * See README.txt for usage instructions.
+ */
+
+#ifndef PSA_CRYPTO_CONFIG_H
+#define PSA_CRYPTO_CONFIG_H
+
+#define PSA_WANT_ALG_CCM                        1
+#define PSA_WANT_ALG_ECB_NO_PADDING             1
+#define PSA_WANT_ALG_HMAC                       1
+#define PSA_WANT_ALG_JPAKE                      1
+#define PSA_WANT_ALG_PBKDF2_AES_CMAC_PRF_128    1
+#define PSA_WANT_ALG_SHA_256                    1
+#define PSA_WANT_ALG_TLS12_PRF                  1
+#define PSA_WANT_ALG_TLS12_ECJPAKE_TO_PMS       1
+#define PSA_WANT_ECC_SECP_R1_256                1
+
+#define PSA_WANT_KEY_TYPE_AES                   1
+#define PSA_WANT_KEY_TYPE_DERIVE                1
+#define PSA_WANT_KEY_TYPE_HMAC                  1
+#define PSA_WANT_KEY_TYPE_RAW_DATA              1
+#define PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_BASIC    1
+#define PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_IMPORT   1
+#define PSA_WANT_KEY_TYPE_ECC_KEY_PAIR_GENERATE 1
+
+#endif /* PSA_CRYPTO_CONFIG_H */
diff --git a/include/mbedtls/config_adjust_legacy_from_psa.h b/include/mbedtls/config_adjust_legacy_from_psa.h
index 0091e246b2..0e4759de74 100644
--- a/include/mbedtls/config_adjust_legacy_from_psa.h
+++ b/include/mbedtls/config_adjust_legacy_from_psa.h
@@ -498,7 +498,6 @@
  * The PSA implementation has its own implementation of HKDF, separate from
  * hkdf.c. No need to enable MBEDTLS_HKDF_C here.
  */
-#define MBEDTLS_PSA_BUILTIN_ALG_HMAC 1
 #define MBEDTLS_PSA_BUILTIN_ALG_HKDF 1
 #endif /* !MBEDTLS_PSA_ACCEL_ALG_HKDF */
 #endif /* PSA_WANT_ALG_HKDF */
@@ -509,7 +508,6 @@
  * The PSA implementation has its own implementation of HKDF, separate from
  * hkdf.c. No need to enable MBEDTLS_HKDF_C here.
  */
-#define MBEDTLS_PSA_BUILTIN_ALG_HMAC 1
 #define MBEDTLS_PSA_BUILTIN_ALG_HKDF_EXTRACT 1
 #endif /* !MBEDTLS_PSA_ACCEL_ALG_HKDF_EXTRACT */
 #endif /* PSA_WANT_ALG_HKDF_EXTRACT */
@@ -520,7 +518,6 @@
  * The PSA implementation has its own implementation of HKDF, separate from
  * hkdf.c. No need to enable MBEDTLS_HKDF_C here.
  */
-#define MBEDTLS_PSA_BUILTIN_ALG_HMAC 1
 #define MBEDTLS_PSA_BUILTIN_ALG_HKDF_EXPAND 1
 #endif /* !MBEDTLS_PSA_ACCEL_ALG_HKDF_EXPAND */
 #endif /* PSA_WANT_ALG_HKDF_EXPAND */
@@ -630,9 +627,6 @@
 #if !defined(MBEDTLS_PSA_ACCEL_ALG_PBKDF2_HMAC)
 #define MBEDTLS_PSA_BUILTIN_ALG_PBKDF2_HMAC 1
 #define PSA_HAVE_SOFT_PBKDF2_HMAC 1
-#if !defined(MBEDTLS_PSA_ACCEL_ALG_HMAC)
-#define MBEDTLS_PSA_BUILTIN_ALG_HMAC 1
-#endif /* !MBEDTLS_PSA_ACCEL_ALG_HMAC */
 #endif /* !MBEDTLS_PSA_BUILTIN_ALG_PBKDF2_HMAC */
 #endif /* PSA_WANT_ALG_PBKDF2_HMAC */
 
diff --git a/include/mbedtls/config_psa.h b/include/mbedtls/config_psa.h
index 17da61b3e8..de961ec0f8 100644
--- a/include/mbedtls/config_psa.h
+++ b/include/mbedtls/config_psa.h
@@ -22,6 +22,8 @@
 
 #include "psa/crypto_adjust_config_synonyms.h"
 
+#include "psa/crypto_adjust_config_dependencies.h"
+
 #include "mbedtls/config_adjust_psa_superset_legacy.h"
 
 #if defined(MBEDTLS_PSA_CRYPTO_CONFIG)
diff --git a/include/psa/crypto_adjust_config_dependencies.h b/include/psa/crypto_adjust_config_dependencies.h
new file mode 100644
index 0000000000..5a22205bf3
--- /dev/null
+++ b/include/psa/crypto_adjust_config_dependencies.h
@@ -0,0 +1,43 @@
+/**
+ * \file psa/crypto_adjust_config_dependencies.h
+ * \brief Adjust PSA configuration by resolving some dependencies.
+ *
+ * This is an internal header. Do not include it directly.
+ *
+ * See docs/proposed/psa-conditional-inclusion-c.md.
+ * If the Mbed TLS implementation of a cryptographic mechanism A depends on a
+ * cryptographic mechanism B then if the cryptographic mechanism A is enabled
+ * and not accelerated enable B. Note that if A is enabled and accelerated, it
+ * is not necessary to enable B for A support.
+ */
+/*
+ *  Copyright The Mbed TLS Contributors
+ *  SPDX-License-Identifier: Apache-2.0 OR GPL-2.0-or-later
+ */
+
+#ifndef PSA_CRYPTO_ADJUST_CONFIG_DEPENDENCIES_H
+#define PSA_CRYPTO_ADJUST_CONFIG_DEPENDENCIES_H
+
+#if (defined(PSA_WANT_ALG_TLS12_PRF) && \
+    !defined(MBEDTLS_PSA_ACCEL_ALG_TLS12_PRF)) || \
+    (defined(PSA_WANT_ALG_TLS12_PSK_TO_MS) && \
+    !defined(MBEDTLS_PSA_ACCEL_ALG_TLS12_PSK_TO_MS)) || \
+    (defined(PSA_WANT_ALG_HKDF) && \
+    !defined(MBEDTLS_PSA_ACCEL_ALG_HKDF)) || \
+    (defined(PSA_WANT_ALG_HKDF_EXTRACT) && \
+    !defined(MBEDTLS_PSA_ACCEL_ALG_HKDF_EXTRACT)) || \
+    (defined(PSA_WANT_ALG_HKDF_EXPAND) && \
+    !defined(MBEDTLS_PSA_ACCEL_ALG_HKDF_EXPAND)) || \
+    (defined(PSA_WANT_ALG_PBKDF2_HMAC) && \
+    !defined(MBEDTLS_PSA_ACCEL_ALG_PBKDF2_HMAC))
+#define PSA_WANT_ALG_HMAC 1
+#define PSA_WANT_KEY_TYPE_HMAC 1
+#endif
+
+#if (defined(PSA_WANT_ALG_PBKDF2_AES_CMAC_PRF_128) && \
+    !defined(MBEDTLS_PSA_ACCEL_ALG_PBKDF2_AES_CMAC_PRF_128))
+#define PSA_WANT_KEY_TYPE_AES 1
+#define PSA_WANT_ALG_CMAC 1
+#endif
+
+#endif /* PSA_CRYPTO_ADJUST_CONFIG_DEPENDENCIES_H */
diff --git a/tests/scripts/all.sh b/tests/scripts/all.sh
index 0bdfb6f157..4f0e9bba14 100755
--- a/tests/scripts/all.sh
+++ b/tests/scripts/all.sh
@@ -1764,6 +1764,7 @@ common_test_full_no_cipher_with_psa_crypto () {
         scripts/config.py -f $CRYPTO_CONFIG_H unset PSA_WANT_ALG_CTR
         scripts/config.py -f $CRYPTO_CONFIG_H unset PSA_WANT_ALG_ECB_NO_PADDING
         scripts/config.py -f $CRYPTO_CONFIG_H unset PSA_WANT_ALG_OFB
+        scripts/config.py -f $CRYPTO_CONFIG_H unset PSA_WANT_ALG_PBKDF2_AES_CMAC_PRF_128
         scripts/config.py -f $CRYPTO_CONFIG_H unset PSA_WANT_ALG_STREAM_CIPHER
         scripts/config.py -f $CRYPTO_CONFIG_H unset PSA_WANT_KEY_TYPE_DES
     else
@@ -4109,6 +4110,7 @@ common_block_cipher_dispatch() {
     scripts/config.py -f "$CRYPTO_CONFIG_H" unset PSA_WANT_ALG_CBC_PKCS7
     scripts/config.py -f "$CRYPTO_CONFIG_H" unset PSA_WANT_ALG_CMAC
     scripts/config.py -f "$CRYPTO_CONFIG_H" unset PSA_WANT_ALG_CCM_STAR_NO_TAG
+    scripts/config.py -f "$CRYPTO_CONFIG_H" unset PSA_WANT_ALG_PBKDF2_AES_CMAC_PRF_128
 
     # Disable direct dependency on AES_C
     scripts/config.py unset MBEDTLS_NIST_KW_C
@@ -5309,9 +5311,11 @@ component_build_psa_config_file () {
     make clean
 
     msg "build: make with MBEDTLS_PSA_CRYPTO_CONFIG_FILE + MBEDTLS_PSA_CRYPTO_USER_CONFIG_FILE" # ~40s
-    # In the user config, disable one feature, which will reflect on the
-    # mbedtls configuration so we can query it with query_compile_time_config.
+    # In the user config, disable one feature and its dependencies, which will
+    # reflect on the mbedtls configuration so we can query it with
+    # query_compile_time_config.
     echo '#undef PSA_WANT_ALG_CMAC' >psa_user_config.h
+    echo '#undef PSA_WANT_ALG_PBKDF2_AES_CMAC_PRF_128' >> psa_user_config.h
     scripts/config.py unset MBEDTLS_CMAC_C
     make CFLAGS="-I '$PWD' -DMBEDTLS_PSA_CRYPTO_CONFIG_FILE='\"psa_test_config.h\"' -DMBEDTLS_PSA_CRYPTO_USER_CONFIG_FILE='\"psa_user_config.h\"'"
     not programs/test/query_compile_time_config MBEDTLS_CMAC_C
diff --git a/tests/scripts/test-ref-configs.pl b/tests/scripts/test-ref-configs.pl
index 055023a5f2..5557de3276 100755
--- a/tests/scripts/test-ref-configs.pl
+++ b/tests/scripts/test-ref-configs.pl
@@ -17,32 +17,26 @@ use strict;
 
 my %configs = (
     'config-ccm-psk-tls1_2.h' => {
-        'compat' => '-m tls12 -f \'^TLS-PSK-WITH-AES-...-CCM-8\'',
-        'test_again_with_use_psa' => 1
+        'compat' => '-m tls12 -f \'^TLS_PSK_WITH_AES_..._CCM_8\'',
     },
     'config-ccm-psk-dtls1_2.h' => {
-        'compat' => '-m dtls12 -f \'^TLS-PSK-WITH-AES-...-CCM-8\'',
+        'compat' => '-m dtls12 -f \'^TLS_PSK_WITH_AES_..._CCM_8\'',
         'opt' => ' ',
         'opt_needs_debug' => 1,
-        'test_again_with_use_psa' => 1
     },
     'config-no-entropy.h' => {
     },
     'config-suite-b.h' => {
-        'compat' => "-m tls12 -f 'ECDHE-ECDSA.*AES.*GCM' -p mbedTLS",
-        'test_again_with_use_psa' => 1,
+        'compat' => "-m tls12 -f 'ECDHE_ECDSA.*AES.*GCM' -p mbedTLS",
         'opt' => ' ',
         'opt_needs_debug' => 1,
     },
     'config-symmetric-only.h' => {
-        'test_again_with_use_psa' => 0, # Uses PSA by default, no need to test it twice
     },
     'config-tfm.h' => {
-        'test_again_with_use_psa' => 0, # Uses PSA by default, no need to test it twice
     },
     'config-thread.h' => {
         'opt' => '-f ECJPAKE.*nolog',
-        'test_again_with_use_psa' => 1,
     },
 );
 
@@ -148,7 +142,10 @@ sub perform_test {
 }
 
 foreach my $conf ( @configs_to_test ) {
-    my $test_with_psa = $configs{$conf}{'test_again_with_use_psa'};
+    system("grep '//#define MBEDTLS_USE_PSA_CRYPTO' configs/$conf > /dev/null");
+    die "grep ... configs/$conf: $!" if $? != 0 && $? != 0x100;
+    my $test_with_psa = $? == 0;
+
     if ( $test_with_psa )
     {
         perform_test( $conf, $configs{$conf}, $test_with_psa );
diff --git a/tests/suites/test_suite_pk.function b/tests/suites/test_suite_pk.function
index ad7da32222..1188137b33 100644
--- a/tests/suites/test_suite_pk.function
+++ b/tests/suites/test_suite_pk.function
@@ -1818,7 +1818,7 @@ void pk_psa_sign(int psa_type, int bits, int rsa_padding)
     int ret;
 #endif /* MBEDTLS_RSA_C || MBEDTLS_PK_WRITE_C */
 #if defined(MBEDTLS_PK_CAN_ECDSA_SIGN)
-    mbedtls_ecp_group_id ecp_grp_id;
+    mbedtls_ecp_group_id ecp_grp_id = MBEDTLS_ECP_DP_NONE;
 #endif /* MBEDTLS_PK_CAN_ECDSA_SIGN */
 
     /*