diff --git a/include/mbedtls/check_config.h b/include/mbedtls/check_config.h
index 67a05f83b8..a17ccb85b4 100644
--- a/include/mbedtls/check_config.h
+++ b/include/mbedtls/check_config.h
@@ -247,6 +247,9 @@
 #if defined(MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN) &&  !defined(MBEDTLS_HAS_MEMSAN)
 #error "MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN requires building with MemorySanitizer"
 #endif
+#if defined(MBEDTLS_HAS_MEMSAN) && defined(MBEDTLS_HAVE_ASM)
+#error "MEMSAN does not support assembly implementation"
+#endif
 #undef MBEDTLS_HAS_MEMSAN // temporary macro defined above
 
 #if defined(MBEDTLS_CCM_C) && \
diff --git a/tests/scripts/components-sanitizers.sh b/tests/scripts/components-sanitizers.sh
index 5b79d2b778..261652a832 100644
--- a/tests/scripts/components-sanitizers.sh
+++ b/tests/scripts/components-sanitizers.sh
@@ -42,6 +42,7 @@ component_test_memsan_constant_flow () {
     scripts/config.py set MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN
     scripts/config.py unset MBEDTLS_USE_PSA_CRYPTO
     scripts/config.py unset MBEDTLS_AESNI_C # memsan doesn't grok asm
+    scripts/config.py unset MBEDTLS_HAVE_ASM
     CC=clang cmake -D CMAKE_BUILD_TYPE:String=MemSan .
     make
 
@@ -60,6 +61,7 @@ component_test_memsan_constant_flow_psa () {
     scripts/config.py full
     scripts/config.py set MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN
     scripts/config.py unset MBEDTLS_AESNI_C # memsan doesn't grok asm
+    scripts/config.py unset MBEDTLS_HAVE_ASM
     CC=clang cmake -D CMAKE_BUILD_TYPE:String=MemSan .
     make