diff --git a/tests/scripts/components-configuration-crypto.sh b/tests/scripts/components-configuration-crypto.sh
index de8ab2d0ce..9cbcddb9cc 100644
--- a/tests/scripts/components-configuration-crypto.sh
+++ b/tests/scripts/components-configuration-crypto.sh
@@ -545,62 +545,31 @@ support_build_crypto_baremetal () {
 # depends.py family of tests
 component_test_depends_py_cipher_id () {
     msg "test/build: depends.py cipher_id (gcc)"
-    tests/scripts/depends.py cipher_id --unset-use-psa
+    tests/scripts/depends.py cipher_id
 }
 
 component_test_depends_py_cipher_chaining () {
     msg "test/build: depends.py cipher_chaining (gcc)"
-    tests/scripts/depends.py cipher_chaining --unset-use-psa
+    tests/scripts/depends.py cipher_chaining
 }
 
 component_test_depends_py_cipher_padding () {
     msg "test/build: depends.py cipher_padding (gcc)"
-    tests/scripts/depends.py cipher_padding --unset-use-psa
+    tests/scripts/depends.py cipher_padding
 }
 
 component_test_depends_py_curves () {
     msg "test/build: depends.py curves (gcc)"
-    tests/scripts/depends.py curves --unset-use-psa
+    tests/scripts/depends.py curves
 }
 
 component_test_depends_py_hashes () {
     msg "test/build: depends.py hashes (gcc)"
-    tests/scripts/depends.py hashes --unset-use-psa
+    tests/scripts/depends.py hashes
 }
 
 component_test_depends_py_pkalgs () {
     msg "test/build: depends.py pkalgs (gcc)"
-    tests/scripts/depends.py pkalgs --unset-use-psa
-}
-
-# PSA equivalents of the depends.py tests
-component_test_depends_py_cipher_id_psa () {
-    msg "test/build: depends.py cipher_id (gcc) with MBEDTLS_USE_PSA_CRYPTO defined"
-    tests/scripts/depends.py cipher_id
-}
-
-component_test_depends_py_cipher_chaining_psa () {
-    msg "test/build: depends.py cipher_chaining (gcc) with MBEDTLS_USE_PSA_CRYPTO defined"
-    tests/scripts/depends.py cipher_chaining
-}
-
-component_test_depends_py_cipher_padding_psa () {
-    msg "test/build: depends.py cipher_padding (gcc) with MBEDTLS_USE_PSA_CRYPTO defined"
-    tests/scripts/depends.py cipher_padding
-}
-
-component_test_depends_py_curves_psa () {
-    msg "test/build: depends.py curves (gcc) with MBEDTLS_USE_PSA_CRYPTO defined"
-    tests/scripts/depends.py curves
-}
-
-component_test_depends_py_hashes_psa () {
-    msg "test/build: depends.py hashes (gcc) with MBEDTLS_USE_PSA_CRYPTO defined"
-    tests/scripts/depends.py hashes
-}
-
-component_test_depends_py_pkalgs_psa () {
-    msg "test/build: depends.py pkalgs (gcc) with MBEDTLS_USE_PSA_CRYPTO defined"
     tests/scripts/depends.py pkalgs
 }
 
diff --git a/tests/scripts/components-configuration-tls.sh b/tests/scripts/components-configuration-tls.sh
index e1d33ad242..b8834d6095 100644
--- a/tests/scripts/components-configuration-tls.sh
+++ b/tests/scripts/components-configuration-tls.sh
@@ -721,11 +721,6 @@ component_test_full_minus_session_tickets () {
 
 component_test_depends_py_kex () {
     msg "test/build: depends.py kex (gcc)"
-    tests/scripts/depends.py kex --unset-use-psa
-}
-
-component_test_depends_py_kex_psa () {
-    msg "test/build: depends.py kex (gcc) with MBEDTLS_USE_PSA_CRYPTO defined"
     tests/scripts/depends.py kex
 }
 
diff --git a/tests/scripts/depends.py b/tests/scripts/depends.py
index 09e14c476c..b77a2cf1ac 100755
--- a/tests/scripts/depends.py
+++ b/tests/scripts/depends.py
@@ -120,7 +120,7 @@ which will make a symbol defined with a certain value."""
         conf.set(option, value)
     return True
 
-def set_reference_config(conf, options, colors):
+def set_reference_config(conf, colors):
     """Change the library configuration file (mbedtls_config.h) to the reference state.
 The reference state is the one from which the tested configurations are
 derived."""
@@ -128,8 +128,6 @@ derived."""
     log_command(['config.py', 'full'])
     conf.adapt(config.full_adapter)
     set_config_option_value(conf, 'MBEDTLS_TEST_HOOKS', colors, False)
-    if options.unset_use_psa:
-        set_config_option_value(conf, 'MBEDTLS_USE_PSA_CRYPTO', colors, False)
 
 class Job:
     """A job builds the library in a specific configuration and runs some tests."""
@@ -159,9 +157,9 @@ If what is False, announce that the job has failed.'''
         else:
             log_line('starting ' + self.name, color=colors.cyan)
 
-    def configure(self, conf, options, colors):
+    def configure(self, conf, colors):
         '''Set library configuration options as required for the job.'''
-        set_reference_config(conf, options, colors)
+        set_reference_config(conf, colors)
         for key, value in sorted(self.config_settings.items()):
             ret = set_config_option_value(conf, key, colors, value)
             if ret is False:
@@ -431,7 +429,7 @@ def run(options, job, conf, colors=NO_COLORS):
     """Run the specified job (a Job instance)."""
     subprocess.check_call([options.make_command, 'clean'])
     job.announce(colors, None)
-    if not job.configure(conf, options, colors):
+    if not job.configure(conf, colors):
         job.announce(colors, False)
         return False
     conf.write()
@@ -514,9 +512,6 @@ def main():
         parser.add_argument('--make-command', metavar='CMD',
                             help='Command to run instead of make (e.g. gmake)',
                             action='store', default='make')
-        parser.add_argument('--unset-use-psa',
-                            help='Unset MBEDTLS_USE_PSA_CRYPTO before any test',
-                            action='store_true', dest='unset_use_psa')
         parser.add_argument('tasks', metavar='TASKS', nargs='*',
                             help='The domain(s) or job(s) to test (default: all).',
                             default=True)