diff --git a/include/mbedtls/ssl.h b/include/mbedtls/ssl.h
index efe08305f2..e541340764 100644
--- a/include/mbedtls/ssl.h
+++ b/include/mbedtls/ssl.h
@@ -1091,13 +1091,13 @@ typedef void mbedtls_ssl_async_cancel_t(mbedtls_ssl_context *ssl);
 #if defined(MBEDTLS_KEY_EXCHANGE_WITH_CERT_ENABLED) &&        \
     !defined(MBEDTLS_SSL_KEEP_PEER_CERTIFICATE)
 #define MBEDTLS_SSL_PEER_CERT_DIGEST_MAX_LEN  48
-#if defined(MBEDTLS_SHA256_C)
+#if defined(MBEDTLS_MD_CAN_SHA256)
 #define MBEDTLS_SSL_PEER_CERT_DIGEST_DFL_TYPE MBEDTLS_MD_SHA256
 #define MBEDTLS_SSL_PEER_CERT_DIGEST_DFL_LEN  32
-#elif defined(MBEDTLS_SHA384_C)
+#elif defined(MBEDTLS_MD_CAN_SHA384)
 #define MBEDTLS_SSL_PEER_CERT_DIGEST_DFL_TYPE MBEDTLS_MD_SHA384
 #define MBEDTLS_SSL_PEER_CERT_DIGEST_DFL_LEN  48
-#elif defined(MBEDTLS_SHA1_C)
+#elif defined(MBEDTLS_MD_CAN_SHA1)
 #define MBEDTLS_SSL_PEER_CERT_DIGEST_DFL_TYPE MBEDTLS_MD_SHA1
 #define MBEDTLS_SSL_PEER_CERT_DIGEST_DFL_LEN  20
 #else
diff --git a/library/hmac_drbg.c b/library/hmac_drbg.c
index b15730235c..af205aacb6 100644
--- a/library/hmac_drbg.c
+++ b/library/hmac_drbg.c
@@ -510,7 +510,7 @@ exit:
 
 #if defined(MBEDTLS_SELF_TEST)
 
-#if !defined(MBEDTLS_SHA1_C)
+#if !defined(MBEDTLS_MD_CAN_SHA1)
 /* Dummy checkup routine */
 int mbedtls_hmac_drbg_self_test(int verbose)
 {
@@ -639,7 +639,7 @@ int mbedtls_hmac_drbg_self_test(int verbose)
 
     return 0;
 }
-#endif /* MBEDTLS_SHA1_C */
+#endif /* MBEDTLS_MD_CAN_SHA1 */
 #endif /* MBEDTLS_SELF_TEST */
 
 #endif /* MBEDTLS_HMAC_DRBG_C */
diff --git a/programs/pkey/dh_client.c b/programs/pkey/dh_client.c
index bc58a153ca..1fbf045460 100644
--- a/programs/pkey/dh_client.c
+++ b/programs/pkey/dh_client.c
@@ -23,9 +23,9 @@
 
 #if defined(MBEDTLS_AES_C) && defined(MBEDTLS_DHM_C) && \
     defined(MBEDTLS_ENTROPY_C) && defined(MBEDTLS_NET_C) && \
-    defined(MBEDTLS_RSA_C) && defined(MBEDTLS_SHA256_C) && \
+    defined(MBEDTLS_RSA_C) && defined(MBEDTLS_MD_CAN_SHA256) && \
     defined(MBEDTLS_FS_IO) && defined(MBEDTLS_CTR_DRBG_C) && \
-    defined(MBEDTLS_SHA1_C)
+    defined(MBEDTLS_MD_CAN_SHA1)
 #include "mbedtls/net_sockets.h"
 #include "mbedtls/aes.h"
 #include "mbedtls/dhm.h"
@@ -43,14 +43,14 @@
 
 #if !defined(MBEDTLS_AES_C) || !defined(MBEDTLS_DHM_C) ||     \
     !defined(MBEDTLS_ENTROPY_C) || !defined(MBEDTLS_NET_C) ||  \
-    !defined(MBEDTLS_RSA_C) || !defined(MBEDTLS_SHA256_C) ||    \
+    !defined(MBEDTLS_RSA_C) || !defined(MBEDTLS_MD_CAN_SHA256) ||    \
     !defined(MBEDTLS_FS_IO) || !defined(MBEDTLS_CTR_DRBG_C) || \
-    !defined(MBEDTLS_SHA1_C)
+    !defined(MBEDTLS_MD_CAN_SHA1)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_AES_C and/or MBEDTLS_DHM_C and/or MBEDTLS_ENTROPY_C "
                    "and/or MBEDTLS_NET_C and/or MBEDTLS_RSA_C and/or "
-                   "MBEDTLS_SHA256_C and/or MBEDTLS_FS_IO and/or "
+                   "MBEDTLS_MD_CAN_SHA256 and/or MBEDTLS_FS_IO and/or "
                    "MBEDTLS_CTR_DRBG_C not defined.\n");
     mbedtls_exit(0);
 }
@@ -280,5 +280,5 @@ exit:
     mbedtls_exit(exit_code);
 }
 #endif /* MBEDTLS_AES_C && MBEDTLS_DHM_C && MBEDTLS_ENTROPY_C &&
-          MBEDTLS_NET_C && MBEDTLS_RSA_C && MBEDTLS_SHA256_C &&
+          MBEDTLS_NET_C && MBEDTLS_RSA_C && MBEDTLS_MD_CAN_SHA256 &&
           MBEDTLS_FS_IO && MBEDTLS_CTR_DRBG_C */
diff --git a/programs/pkey/dh_server.c b/programs/pkey/dh_server.c
index 2514fc05cb..66f7d6f350 100644
--- a/programs/pkey/dh_server.c
+++ b/programs/pkey/dh_server.c
@@ -23,9 +23,9 @@
 
 #if defined(MBEDTLS_AES_C) && defined(MBEDTLS_DHM_C) && \
     defined(MBEDTLS_ENTROPY_C) && defined(MBEDTLS_NET_C) && \
-    defined(MBEDTLS_RSA_C) && defined(MBEDTLS_SHA256_C) && \
+    defined(MBEDTLS_RSA_C) && defined(MBEDTLS_MD_CAN_SHA256) && \
     defined(MBEDTLS_FS_IO) && defined(MBEDTLS_CTR_DRBG_C) && \
-    defined(MBEDTLS_SHA1_C)
+    defined(MBEDTLS_MD_CAN_SHA1)
 #include "mbedtls/net_sockets.h"
 #include "mbedtls/aes.h"
 #include "mbedtls/dhm.h"
@@ -43,14 +43,14 @@
 
 #if !defined(MBEDTLS_AES_C) || !defined(MBEDTLS_DHM_C) ||     \
     !defined(MBEDTLS_ENTROPY_C) || !defined(MBEDTLS_NET_C) ||  \
-    !defined(MBEDTLS_RSA_C) || !defined(MBEDTLS_SHA256_C) ||    \
+    !defined(MBEDTLS_RSA_C) || !defined(MBEDTLS_MD_CAN_SHA256) ||    \
     !defined(MBEDTLS_FS_IO) || !defined(MBEDTLS_CTR_DRBG_C) || \
-    !defined(MBEDTLS_SHA1_C)
+    !defined(MBEDTLS_MD_CAN_SHA1)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_AES_C and/or MBEDTLS_DHM_C and/or MBEDTLS_ENTROPY_C "
                    "and/or MBEDTLS_NET_C and/or MBEDTLS_RSA_C and/or "
-                   "MBEDTLS_SHA256_C and/or MBEDTLS_FS_IO and/or "
+                   "MBEDTLS_MD_CAN_SHA256 and/or MBEDTLS_FS_IO and/or "
                    "MBEDTLS_CTR_DRBG_C not defined.\n");
     mbedtls_exit(0);
 }
@@ -302,5 +302,5 @@ exit:
     mbedtls_exit(exit_code);
 }
 #endif /* MBEDTLS_AES_C && MBEDTLS_DHM_C && MBEDTLS_ENTROPY_C &&
-          MBEDTLS_NET_C && MBEDTLS_RSA_C && MBEDTLS_SHA256_C &&
+          MBEDTLS_NET_C && MBEDTLS_RSA_C && MBEDTLS_MD_CAN_SHA256 &&
           MBEDTLS_FS_IO && MBEDTLS_CTR_DRBG_C */
diff --git a/programs/pkey/pk_sign.c b/programs/pkey/pk_sign.c
index 21a75e9272..f3bcdb24ab 100644
--- a/programs/pkey/pk_sign.c
+++ b/programs/pkey/pk_sign.c
@@ -22,13 +22,13 @@
 #include "mbedtls/platform.h"
 
 #if !defined(MBEDTLS_BIGNUM_C) || !defined(MBEDTLS_ENTROPY_C) ||  \
-    !defined(MBEDTLS_SHA256_C) || !defined(MBEDTLS_MD_C) || \
+    !defined(MBEDTLS_MD_CAN_SHA256) || !defined(MBEDTLS_MD_C) || \
     !defined(MBEDTLS_PK_PARSE_C) || !defined(MBEDTLS_FS_IO) ||    \
     !defined(MBEDTLS_CTR_DRBG_C)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_BIGNUM_C and/or MBEDTLS_ENTROPY_C and/or "
-                   "MBEDTLS_SHA256_C and/or MBEDTLS_MD_C and/or "
+                   "MBEDTLS_MD_CAN_SHA256 and/or MBEDTLS_MD_C and/or "
                    "MBEDTLS_PK_PARSE_C and/or MBEDTLS_FS_IO and/or "
                    "MBEDTLS_CTR_DRBG_C not defined.\n");
     mbedtls_exit(0);
@@ -150,5 +150,5 @@ exit:
     mbedtls_exit(exit_code);
 }
 #endif /* MBEDTLS_BIGNUM_C && MBEDTLS_ENTROPY_C &&
-          MBEDTLS_SHA256_C && MBEDTLS_PK_PARSE_C && MBEDTLS_FS_IO &&
+          MBEDTLS_MD_CAN_SHA256 && MBEDTLS_PK_PARSE_C && MBEDTLS_FS_IO &&
           MBEDTLS_CTR_DRBG_C */
diff --git a/programs/pkey/pk_verify.c b/programs/pkey/pk_verify.c
index b1fd1b646d..e24f27f0c0 100644
--- a/programs/pkey/pk_verify.c
+++ b/programs/pkey/pk_verify.c
@@ -22,12 +22,12 @@
 #include "mbedtls/platform.h"
 
 #if !defined(MBEDTLS_BIGNUM_C) || !defined(MBEDTLS_MD_C) || \
-    !defined(MBEDTLS_SHA256_C) || !defined(MBEDTLS_PK_PARSE_C) ||   \
+    !defined(MBEDTLS_MD_CAN_SHA256) || !defined(MBEDTLS_PK_PARSE_C) ||   \
     !defined(MBEDTLS_FS_IO)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_BIGNUM_C and/or MBEDTLS_MD_C and/or "
-                   "MBEDTLS_SHA256_C and/or MBEDTLS_PK_PARSE_C and/or "
+                   "MBEDTLS_MD_CAN_SHA256 and/or MBEDTLS_PK_PARSE_C and/or "
                    "MBEDTLS_FS_IO not defined.\n");
     mbedtls_exit(0);
 }
@@ -123,5 +123,5 @@ exit:
 
     mbedtls_exit(exit_code);
 }
-#endif /* MBEDTLS_BIGNUM_C && MBEDTLS_SHA256_C &&
+#endif /* MBEDTLS_BIGNUM_C && MBEDTLS_MD_CAN_SHA256 &&
           MBEDTLS_PK_PARSE_C && MBEDTLS_FS_IO */
diff --git a/programs/pkey/rsa_sign.c b/programs/pkey/rsa_sign.c
index a8418d145f..051db07c06 100644
--- a/programs/pkey/rsa_sign.c
+++ b/programs/pkey/rsa_sign.c
@@ -22,13 +22,13 @@
 #include "mbedtls/platform.h"
 
 #if !defined(MBEDTLS_BIGNUM_C) || !defined(MBEDTLS_RSA_C) ||  \
-    !defined(MBEDTLS_SHA256_C) || !defined(MBEDTLS_MD_C) || \
+    !defined(MBEDTLS_MD_CAN_SHA256) || !defined(MBEDTLS_MD_C) || \
     !defined(MBEDTLS_FS_IO)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_BIGNUM_C and/or MBEDTLS_RSA_C and/or "
                    "MBEDTLS_MD_C and/or "
-                   "MBEDTLS_SHA256_C and/or MBEDTLS_FS_IO not defined.\n");
+                   "MBEDTLS_MD_CAN_SHA256 and/or MBEDTLS_FS_IO not defined.\n");
     mbedtls_exit(0);
 }
 #else
@@ -162,5 +162,5 @@ exit:
 
     mbedtls_exit(exit_code);
 }
-#endif /* MBEDTLS_BIGNUM_C && MBEDTLS_RSA_C && MBEDTLS_SHA256_C &&
+#endif /* MBEDTLS_BIGNUM_C && MBEDTLS_RSA_C && MBEDTLS_MD_CAN_SHA256 &&
           MBEDTLS_FS_IO */
diff --git a/programs/pkey/rsa_sign_pss.c b/programs/pkey/rsa_sign_pss.c
index 19ab962e4f..4fa3582a75 100644
--- a/programs/pkey/rsa_sign_pss.c
+++ b/programs/pkey/rsa_sign_pss.c
@@ -22,13 +22,13 @@
 #include "mbedtls/platform.h"
 
 #if !defined(MBEDTLS_MD_C) || !defined(MBEDTLS_ENTROPY_C) ||  \
-    !defined(MBEDTLS_RSA_C) || !defined(MBEDTLS_SHA256_C) ||        \
+    !defined(MBEDTLS_RSA_C) || !defined(MBEDTLS_MD_CAN_SHA256) ||        \
     !defined(MBEDTLS_PK_PARSE_C) || !defined(MBEDTLS_FS_IO) ||    \
     !defined(MBEDTLS_CTR_DRBG_C)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_MD_C and/or MBEDTLS_ENTROPY_C and/or "
-                   "MBEDTLS_RSA_C and/or MBEDTLS_SHA256_C and/or "
+                   "MBEDTLS_RSA_C and/or MBEDTLS_MD_CAN_SHA256 and/or "
                    "MBEDTLS_PK_PARSE_C and/or MBEDTLS_FS_IO and/or "
                    "MBEDTLS_CTR_DRBG_C not defined.\n");
     mbedtls_exit(0);
@@ -156,5 +156,5 @@ exit:
     mbedtls_exit(exit_code);
 }
 #endif /* MBEDTLS_BIGNUM_C && MBEDTLS_ENTROPY_C && MBEDTLS_RSA_C &&
-          MBEDTLS_SHA256_C && MBEDTLS_PK_PARSE_C && MBEDTLS_FS_IO &&
+          MBEDTLS_MD_CAN_SHA256 && MBEDTLS_PK_PARSE_C && MBEDTLS_FS_IO &&
           MBEDTLS_CTR_DRBG_C */
diff --git a/programs/pkey/rsa_verify.c b/programs/pkey/rsa_verify.c
index 9c08435cd8..e17d776f8d 100644
--- a/programs/pkey/rsa_verify.c
+++ b/programs/pkey/rsa_verify.c
@@ -22,13 +22,13 @@
 #include "mbedtls/platform.h"
 
 #if !defined(MBEDTLS_BIGNUM_C) || !defined(MBEDTLS_RSA_C) ||  \
-    !defined(MBEDTLS_SHA256_C) || !defined(MBEDTLS_MD_C) || \
+    !defined(MBEDTLS_MD_CAN_SHA256) || !defined(MBEDTLS_MD_C) || \
     !defined(MBEDTLS_FS_IO)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_BIGNUM_C and/or MBEDTLS_RSA_C and/or "
                    "MBEDTLS_MD_C and/or "
-                   "MBEDTLS_SHA256_C and/or MBEDTLS_FS_IO not defined.\n");
+                   "MBEDTLS_MD_CAN_SHA256 and/or MBEDTLS_FS_IO not defined.\n");
     mbedtls_exit(0);
 }
 #else
@@ -138,5 +138,5 @@ exit:
 
     mbedtls_exit(exit_code);
 }
-#endif /* MBEDTLS_BIGNUM_C && MBEDTLS_RSA_C && MBEDTLS_SHA256_C &&
+#endif /* MBEDTLS_BIGNUM_C && MBEDTLS_RSA_C && MBEDTLS_MD_CAN_SHA256 &&
           MBEDTLS_FS_IO */
diff --git a/programs/pkey/rsa_verify_pss.c b/programs/pkey/rsa_verify_pss.c
index df61e4712a..bbd8c17b28 100644
--- a/programs/pkey/rsa_verify_pss.c
+++ b/programs/pkey/rsa_verify_pss.c
@@ -22,13 +22,13 @@
 #include "mbedtls/platform.h"
 
 #if !defined(MBEDTLS_MD_C) || !defined(MBEDTLS_ENTROPY_C) ||  \
-    !defined(MBEDTLS_RSA_C) || !defined(MBEDTLS_SHA256_C) ||        \
+    !defined(MBEDTLS_RSA_C) || !defined(MBEDTLS_MD_CAN_SHA256) ||        \
     !defined(MBEDTLS_PK_PARSE_C) || !defined(MBEDTLS_FS_IO) ||    \
     !defined(MBEDTLS_CTR_DRBG_C)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_MD_C and/or MBEDTLS_ENTROPY_C and/or "
-                   "MBEDTLS_RSA_C and/or MBEDTLS_SHA256_C and/or "
+                   "MBEDTLS_RSA_C and/or MBEDTLS_MD_CAN_SHA256 and/or "
                    "MBEDTLS_PK_PARSE_C and/or MBEDTLS_FS_IO and/or "
                    "MBEDTLS_CTR_DRBG_C not defined.\n");
     mbedtls_exit(0);
@@ -131,5 +131,5 @@ exit:
 
     mbedtls_exit(exit_code);
 }
-#endif /* MBEDTLS_BIGNUM_C && MBEDTLS_RSA_C && MBEDTLS_SHA256_C &&
+#endif /* MBEDTLS_BIGNUM_C && MBEDTLS_RSA_C && MBEDTLS_MD_CAN_SHA256 &&
           MBEDTLS_PK_PARSE_C && MBEDTLS_FS_IO */
diff --git a/programs/x509/cert_req.c b/programs/x509/cert_req.c
index 5241438440..01d09bc013 100644
--- a/programs/x509/cert_req.c
+++ b/programs/x509/cert_req.c
@@ -22,13 +22,13 @@
 #include "mbedtls/platform.h"
 
 #if !defined(MBEDTLS_X509_CSR_WRITE_C) || !defined(MBEDTLS_FS_IO) ||  \
-    !defined(MBEDTLS_PK_PARSE_C) || !defined(MBEDTLS_SHA256_C) || \
+    !defined(MBEDTLS_PK_PARSE_C) || !defined(MBEDTLS_MD_CAN_SHA256) || \
     !defined(MBEDTLS_ENTROPY_C) || !defined(MBEDTLS_CTR_DRBG_C) || \
     !defined(MBEDTLS_PEM_WRITE_C)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_X509_CSR_WRITE_C and/or MBEDTLS_FS_IO and/or "
-                   "MBEDTLS_PK_PARSE_C and/or MBEDTLS_SHA256_C and/or "
+                   "MBEDTLS_PK_PARSE_C and/or MBEDTLS_MD_CAN_SHA256 and/or "
                    "MBEDTLS_ENTROPY_C and/or MBEDTLS_CTR_DRBG_C "
                    "not defined.\n");
     mbedtls_exit(0);
diff --git a/programs/x509/cert_write.c b/programs/x509/cert_write.c
index 0daee56270..99ede78fae 100644
--- a/programs/x509/cert_write.c
+++ b/programs/x509/cert_write.c
@@ -24,12 +24,12 @@
 #if !defined(MBEDTLS_X509_CRT_WRITE_C) || \
     !defined(MBEDTLS_X509_CRT_PARSE_C) || !defined(MBEDTLS_FS_IO) || \
     !defined(MBEDTLS_ENTROPY_C) || !defined(MBEDTLS_CTR_DRBG_C) || \
-    !defined(MBEDTLS_ERROR_C) || !defined(MBEDTLS_SHA256_C) || \
+    !defined(MBEDTLS_ERROR_C) || !defined(MBEDTLS_MD_CAN_SHA256) || \
     !defined(MBEDTLS_PEM_WRITE_C)
 int main(void)
 {
     mbedtls_printf("MBEDTLS_X509_CRT_WRITE_C and/or MBEDTLS_X509_CRT_PARSE_C and/or "
-                   "MBEDTLS_FS_IO and/or MBEDTLS_SHA256_C and/or "
+                   "MBEDTLS_FS_IO and/or MBEDTLS_MD_CAN_SHA256 and/or "
                    "MBEDTLS_ENTROPY_C and/or MBEDTLS_CTR_DRBG_C and/or "
                    "MBEDTLS_ERROR_C not defined.\n");
     mbedtls_exit(0);
@@ -771,7 +771,7 @@ usage:
         mbedtls_printf(" ok\n");
     }
 
-#if defined(MBEDTLS_SHA1_C)
+#if defined(MBEDTLS_MD_CAN_SHA1)
     if (opt.version == MBEDTLS_X509_CRT_VERSION_3 &&
         opt.subject_identifier != 0) {
         mbedtls_printf("  . Adding the Subject Key Identifier ...");
@@ -805,7 +805,7 @@ usage:
 
         mbedtls_printf(" ok\n");
     }
-#endif /* MBEDTLS_SHA1_C */
+#endif /* MBEDTLS_MD_CAN_SHA1 */
 
     if (opt.version == MBEDTLS_X509_CRT_VERSION_3 &&
         opt.key_usage != 0) {
diff --git a/tests/scripts/generate_pkcs7_tests.py b/tests/scripts/generate_pkcs7_tests.py
index 187debc92b..0e73850434 100755
--- a/tests/scripts/generate_pkcs7_tests.py
+++ b/tests/scripts/generate_pkcs7_tests.py
@@ -49,7 +49,7 @@ class TestData:
     Take in test_suite_pkcs7.data file.
     Allow for new tests to be added.
     """
-    mandatory_dep = "MBEDTLS_SHA256_C"
+    mandatory_dep = "MBEDTLS_MD_CAN_SHA256"
     test_name = "PKCS7 Parse Failure Invalid ASN1"
     test_function = "pkcs7_asn1_fail:"
     def __init__(self, file_name):
diff --git a/tests/suites/test_suite_random.data b/tests/suites/test_suite_random.data
index c23d9223f6..9211591a55 100644
--- a/tests/suites/test_suite_random.data
+++ b/tests/suites/test_suite_random.data
@@ -2,15 +2,15 @@ Generate random twice with CTR_DRBG
 random_twice_with_ctr_drbg:
 
 Generate random twice with HMAC_DRBG(SHA-1)
-depends_on:MBEDTLS_SHA1_C
+depends_on:MBEDTLS_MD_CAN_SHA1
 random_twice_with_hmac_drbg:MBEDTLS_MD_SHA1
 
 Generate random twice with HMAC_DRBG(SHA-256)
-depends_on:MBEDTLS_SHA256_C
+depends_on:MBEDTLS_MD_CAN_SHA256
 random_twice_with_hmac_drbg:MBEDTLS_MD_SHA256
 
 Generate random twice with HMAC_DRBG(SHA-512)
-depends_on:MBEDTLS_SHA512_C
+depends_on:MBEDTLS_MD_CAN_SHA512
 random_twice_with_hmac_drbg:MBEDTLS_MD_SHA512
 
 Generate random twice with PSA classic wrapper