diff --git a/include/mbedtls/config_psa.h b/include/mbedtls/config_psa.h
index f9171330d7..edf62827ea 100644
--- a/include/mbedtls/config_psa.h
+++ b/include/mbedtls/config_psa.h
@@ -260,7 +260,6 @@ extern "C" {
 #if (defined(PSA_WANT_ALG_CTR) && !defined(MBEDTLS_PSA_ACCEL_ALG_CTR)) || \
     (defined(PSA_WANT_ALG_CFB) && !defined(MBEDTLS_PSA_ACCEL_ALG_CFB)) || \
     (defined(PSA_WANT_ALG_OFB) && !defined(MBEDTLS_PSA_ACCEL_ALG_OFB)) || \
-    (defined(PSA_WANT_ALG_XTS) && !defined(MBEDTLS_PSA_ACCEL_ALG_XTS)) || \
     defined(PSA_WANT_ALG_ECB_NO_PADDING) || \
     (defined(PSA_WANT_ALG_CBC_NO_PADDING) && \
      !defined(MBEDTLS_PSA_ACCEL_ALG_CBC_NO_PADDING)) || \
@@ -382,14 +381,6 @@ extern "C" {
 #endif
 #endif /* PSA_WANT_ALG_OFB */
 
-#if defined(PSA_WANT_ALG_XTS)
-#if !defined(MBEDTLS_PSA_ACCEL_ALG_XTS) || \
-    defined(PSA_HAVE_SOFT_BLOCK_CIPHER)
-#define MBEDTLS_PSA_BUILTIN_ALG_XTS 1
-#define MBEDTLS_CIPHER_MODE_XTS
-#endif
-#endif /* PSA_WANT_ALG_XTS */
-
 #if defined(PSA_WANT_ALG_ECB_NO_PADDING) &&     \
     !defined(MBEDTLS_PSA_ACCEL_ALG_ECB_NO_PADDING)
 #define MBEDTLS_PSA_BUILTIN_ALG_ECB_NO_PADDING 1
@@ -726,11 +717,6 @@ extern "C" {
 #define PSA_WANT_ALG_OFB 1
 #endif
 
-#if defined(MBEDTLS_CIPHER_MODE_XTS)
-#define MBEDTLS_PSA_BUILTIN_ALG_XTS 1
-#define PSA_WANT_ALG_XTS 1
-#endif
-
 #if defined(MBEDTLS_ECP_DP_BP256R1_ENABLED)
 #define MBEDTLS_PSA_BUILTIN_ECC_BRAINPOOL_P_R1_256 1
 #define PSA_WANT_ECC_BRAINPOOL_P_R1_256
diff --git a/include/psa/crypto_builtin_primitives.h b/include/psa/crypto_builtin_primitives.h
index d3cf33a9dd..35f3a8b30b 100644
--- a/include/psa/crypto_builtin_primitives.h
+++ b/include/psa/crypto_builtin_primitives.h
@@ -94,7 +94,6 @@ typedef struct
     defined(MBEDTLS_PSA_BUILTIN_ALG_CTR) || \
     defined(MBEDTLS_PSA_BUILTIN_ALG_CFB) || \
     defined(MBEDTLS_PSA_BUILTIN_ALG_OFB) || \
-    defined(MBEDTLS_PSA_BUILTIN_ALG_XTS) || \
     defined(MBEDTLS_PSA_BUILTIN_ALG_ECB_NO_PADDING) || \
     defined(MBEDTLS_PSA_BUILTIN_ALG_CBC_NO_PADDING) || \
     defined(MBEDTLS_PSA_BUILTIN_ALG_CBC_PKCS7)
diff --git a/include/psa/crypto_config.h b/include/psa/crypto_config.h
index d290971f89..46cf1265f7 100644
--- a/include/psa/crypto_config.h
+++ b/include/psa/crypto_config.h
@@ -87,7 +87,9 @@
 #define PSA_WANT_ALG_STREAM_CIPHER              1
 #define PSA_WANT_ALG_TLS12_PRF                  1
 #define PSA_WANT_ALG_TLS12_PSK_TO_MS            1
-#define PSA_WANT_ALG_XTS                        1
+/* PBKDF2-HMAC is not yet supported via the PSA API in Mbed TLS.
+ * Note: when adding support, also adjust include/mbedtls/config_psa.h */
+//#define PSA_WANT_ALG_XTS                        1
 
 #define PSA_WANT_ECC_BRAINPOOL_P_R1_256         1
 #define PSA_WANT_ECC_BRAINPOOL_P_R1_384         1