diff --git a/tests/include/test/drivers/crypto_config_test_driver_extension.h b/tests/include/test/drivers/crypto_config_test_driver_extension.h
index af4686b97e..927009ad96 100644
--- a/tests/include/test/drivers/crypto_config_test_driver_extension.h
+++ b/tests/include/test/drivers/crypto_config_test_driver_extension.h
@@ -54,22 +54,6 @@
 #endif
 #endif
 
-#if defined(PSA_WANT_ALG_MD2)
-#if defined(MBEDTLS_PSA_ACCEL_ALG_MD2)
-#undef MBEDTLS_PSA_ACCEL_ALG_MD2
-#else
-#define MBEDTLS_PSA_ACCEL_ALG_MD2 1
-#endif
-#endif
-
-#if defined(PSA_WANT_ALG_MD4)
-#if defined(MBEDTLS_PSA_ACCEL_ALG_MD4)
-#undef MBEDTLS_PSA_ACCEL_ALG_MD4
-#else
-#define MBEDTLS_PSA_ACCEL_ALG_MD4 1
-#endif
-#endif
-
 #if defined(PSA_WANT_ALG_MD5)
 #if defined(MBEDTLS_PSA_ACCEL_ALG_MD5)
 #undef MBEDTLS_PSA_ACCEL_ALG_MD5
@@ -231,7 +215,6 @@
 
 #define MBEDTLS_PSA_ACCEL_KEY_TYPE_DERIVE 1
 #define MBEDTLS_PSA_ACCEL_KEY_TYPE_HMAC 1
-#define MBEDTLS_PSA_ACCEL_KEY_TYPE_ARC4 1
 #define MBEDTLS_PSA_ACCEL_KEY_TYPE_CHACHA20 1
 #define MBEDTLS_PSA_ACCEL_KEY_TYPE_DES 1
 #define MBEDTLS_PSA_ACCEL_KEY_TYPE_ECC_PUBLIC_KEY 1
diff --git a/tests/include/test/psa_exercise_key.h b/tests/include/test/psa_exercise_key.h
index 6cffeb22bf..18333a9372 100644
--- a/tests/include/test/psa_exercise_key.h
+++ b/tests/include/test/psa_exercise_key.h
@@ -60,11 +60,7 @@
  * part of another algorithm like a signature algorithm and the hashing is
  * completed through an Mbed TLS hash API, not the PSA one.
  */
-#if defined(MBEDTLS_MD2_C)
-#define KNOWN_MBEDTLS_SUPPORTED_HASH_ALG PSA_ALG_MD2
-#elif defined(MBEDTLS_MD4_C)
-#define KNOWN_MBEDTLS_SUPPORTED_HASH_ALG PSA_ALG_MD4
-#elif defined(MBEDTLS_MD5_C)
+#if defined(MBEDTLS_MD5_C)
 #define KNOWN_MBEDTLS_SUPPORTED_HASH_ALG PSA_ALG_MD5
 /* MBEDTLS_RIPEMD160_C omitted. This is necessary for the sake of
  * exercise_signature_key() because Mbed TLS doesn't support RIPEMD160
diff --git a/tests/scripts/all.sh b/tests/scripts/all.sh
index 219be42023..27b86dcdc9 100755
--- a/tests/scripts/all.sh
+++ b/tests/scripts/all.sh
@@ -1620,8 +1620,6 @@ component_test_psa_crypto_config_accel_rsa_signature () {
     #   PSA_ALG_ANY_HASH as algorithm to test with the key, the chosen hash
     #   algorithm based on the hashes supported by the library is also
     #   supported by the test library.
-    scripts/config.py -f include/psa/crypto_config.h unset PSA_WANT_ALG_MD2
-    scripts/config.py -f include/psa/crypto_config.h unset PSA_WANT_ALG_MD4
     scripts/config.py -f include/psa/crypto_config.h unset PSA_WANT_ALG_MD5
     scripts/config.py -f include/psa/crypto_config.h unset PSA_WANT_ALG_RIPEMD160_C
 
@@ -1658,8 +1656,6 @@ component_test_psa_crypto_config_accel_rsa_signature () {
     scripts/config.py unset MBEDTLS_RSA_C
     scripts/config.py unset MBEDTLS_X509_RSASSA_PSS_SUPPORT
 
-    scripts/config.py unset MBEDTLS_MD2_C
-    scripts/config.py unset MBEDTLS_MD4_C
     scripts/config.py unset MBEDTLS_MD5_C
     scripts/config.py unset MBEDTLS_RIPEMD160_C
     scripts/config.py unset MBEDTLS_SSL_PROTO_TLS1
@@ -1687,14 +1683,12 @@ component_test_psa_crypto_config_accel_hash () {
     scripts/config.py -f include/psa/crypto_config.h unset PSA_WANT_ALG_STREAM_CIPHER
     scripts/config.py -f include/psa/crypto_config.h unset PSA_WANT_ALG_ECB_NO_PADDING
 
-    loc_accel_list="ALG_MD4 ALG_MD5 ALG_RIPEMD160 ALG_SHA_1 ALG_SHA_224 ALG_SHA_256 ALG_SHA_384 ALG_SHA_512"
+    loc_accel_list="ALG_MD5 ALG_RIPEMD160 ALG_SHA_1 ALG_SHA_224 ALG_SHA_256 ALG_SHA_384 ALG_SHA_512"
     loc_accel_flags=$( echo "$loc_accel_list" | sed 's/[^ ]* */-DLIBTESTDRIVER1_MBEDTLS_PSA_ACCEL_&/g' )
     make -C tests libtestdriver1.a CFLAGS="$ASAN_CFLAGS $loc_accel_flags" LDFLAGS="$ASAN_CFLAGS"
 
     scripts/config.py set MBEDTLS_PSA_CRYPTO_DRIVERS
     scripts/config.py set MBEDTLS_PSA_CRYPTO_CONFIG
-    scripts/config.py unset MBEDTLS_MD2_C
-    scripts/config.py unset MBEDTLS_MD4_C
     scripts/config.py unset MBEDTLS_MD5_C
     scripts/config.py unset MBEDTLS_RIPEMD160_C
     scripts/config.py unset MBEDTLS_SHA1_C