diff --git a/Source/Core/DolphinWX/Cheats/GeckoCodeDiag.cpp b/Source/Core/DolphinWX/Cheats/GeckoCodeDiag.cpp
index 9ef181354a..4fb77fdb65 100644
--- a/Source/Core/DolphinWX/Cheats/GeckoCodeDiag.cpp
+++ b/Source/Core/DolphinWX/Cheats/GeckoCodeDiag.cpp
@@ -23,6 +23,8 @@
 #include "DolphinWX/Cheats/GeckoCodeDiag.h"
 #include "DolphinWX/WxUtils.h"
 
+wxDEFINE_EVENT(DOLPHIN_EVT_GECKOCODE_TOGGLED, wxCommandEvent);
+
 namespace Gecko
 {
 static const wxString wxstr_name(wxTRANSLATE("Name: ")), wxstr_notes(wxTRANSLATE("Notes: ")),
@@ -108,7 +110,13 @@ void CodeConfigPanel::ToggleCode(wxCommandEvent& evt)
 {
   const int sel = evt.GetInt();  // this right?
   if (sel > -1)
+  {
     m_gcodes[sel].enabled = m_listbox_gcodes->IsChecked(sel);
+
+    wxCommandEvent toggle_event(DOLPHIN_EVT_GECKOCODE_TOGGLED, GetId());
+    toggle_event.SetClientData(&m_gcodes[sel]);
+    GetEventHandler()->ProcessEvent(toggle_event);
+  }
 }
 
 void CodeConfigPanel::UpdateInfoBox(wxCommandEvent&)
diff --git a/Source/Core/DolphinWX/Cheats/GeckoCodeDiag.h b/Source/Core/DolphinWX/Cheats/GeckoCodeDiag.h
index 317f84f205..724dc76939 100644
--- a/Source/Core/DolphinWX/Cheats/GeckoCodeDiag.h
+++ b/Source/Core/DolphinWX/Cheats/GeckoCodeDiag.h
@@ -17,6 +17,9 @@ class wxListBox;
 class wxStaticText;
 class wxTextCtrl;
 
+// GetClientData() -> GeckoCode* [immutable]
+wxDECLARE_EVENT(DOLPHIN_EVT_GECKOCODE_TOGGLED, wxCommandEvent);
+
 namespace Gecko
 {
 class CodeConfigPanel : public wxPanel
diff --git a/Source/Core/DolphinWX/Frame.h b/Source/Core/DolphinWX/Frame.h
index cbcee5e374..01285c3a37 100644
--- a/Source/Core/DolphinWX/Frame.h
+++ b/Source/Core/DolphinWX/Frame.h
@@ -109,6 +109,7 @@ public:
   void PopulateSavedPerspectives();
   static void ConnectWiimote(int wm_idx, bool connect);
   void UpdateTitle(const std::string& str);
+  void OpenGeneralConfiguration(int tab = -1);
 
   const CGameListCtrl* GetGameListCtrl() const;
   wxMenuBar* GetMenuBar() const override;
diff --git a/Source/Core/DolphinWX/FrameTools.cpp b/Source/Core/DolphinWX/FrameTools.cpp
index 4dc8789796..2fdf38a02f 100644
--- a/Source/Core/DolphinWX/FrameTools.cpp
+++ b/Source/Core/DolphinWX/FrameTools.cpp
@@ -600,6 +600,20 @@ void CFrame::InitBitmaps()
     RecreateToolbar();
 }
 
+void CFrame::OpenGeneralConfiguration(int tab)
+{
+  CConfigMain config_main(this);
+  if (tab > -1)
+    config_main.SetSelectedTab(tab);
+
+  HotkeyManagerEmu::Enable(false);
+  if (config_main.ShowModal() == wxID_OK)
+    m_GameListCtrl->Update();
+  HotkeyManagerEmu::Enable(true);
+
+  UpdateGUI();
+}
+
 // Menu items
 
 // Start the game or change the disc.
@@ -1300,12 +1314,7 @@ void CFrame::OnReset(wxCommandEvent& WXUNUSED(event))
 
 void CFrame::OnConfigMain(wxCommandEvent& WXUNUSED(event))
 {
-  CConfigMain ConfigMain(this);
-  HotkeyManagerEmu::Enable(false);
-  if (ConfigMain.ShowModal() == wxID_OK)
-    m_GameListCtrl->Update();
-  HotkeyManagerEmu::Enable(true);
-  UpdateGUI();
+  OpenGeneralConfiguration();
 }
 
 void CFrame::OnConfigGFX(wxCommandEvent& WXUNUSED(event))
@@ -1318,12 +1327,7 @@ void CFrame::OnConfigGFX(wxCommandEvent& WXUNUSED(event))
 
 void CFrame::OnConfigAudio(wxCommandEvent& WXUNUSED(event))
 {
-  CConfigMain ConfigMain(this);
-  ConfigMain.SetSelectedTab(CConfigMain::ID_AUDIOPAGE);
-  HotkeyManagerEmu::Enable(false);
-  if (ConfigMain.ShowModal() == wxID_OK)
-    m_GameListCtrl->Update();
-  HotkeyManagerEmu::Enable(true);
+  OpenGeneralConfiguration(CConfigMain::ID_AUDIOPAGE);
 }
 
 void CFrame::OnConfigControllers(wxCommandEvent& WXUNUSED(event))
diff --git a/Source/Core/DolphinWX/ISOProperties.cpp b/Source/Core/DolphinWX/ISOProperties.cpp
index e8b30dddfe..339ff592bf 100644
--- a/Source/Core/DolphinWX/ISOProperties.cpp
+++ b/Source/Core/DolphinWX/ISOProperties.cpp
@@ -17,6 +17,7 @@
 #include <type_traits>
 #include <vector>
 #include <wx/app.h>
+#include <wx/artprov.h>
 #include <wx/bitmap.h>
 #include <wx/button.h>
 #include <wx/checkbox.h>
@@ -56,6 +57,7 @@
 #include "Common/SysConf.h"
 #include "Core/Boot/Boot.h"
 #include "Core/ConfigManager.h"
+#include "Core/Core.h"
 #include "Core/GeckoCodeConfig.h"
 #include "Core/PatchEngine.h"
 #include "DiscIO/Blob.h"
@@ -65,12 +67,126 @@
 #include "DiscIO/VolumeCreator.h"
 #include "DolphinWX/Cheats/ActionReplayCodesPanel.h"
 #include "DolphinWX/Cheats/GeckoCodeDiag.h"
+#include "DolphinWX/Frame.h"
 #include "DolphinWX/Globals.h"
 #include "DolphinWX/ISOFile.h"
 #include "DolphinWX/ISOProperties.h"
+#include "DolphinWX/Main.h"
 #include "DolphinWX/PatchAddEdit.h"
 #include "DolphinWX/WxUtils.h"
 
+// A warning message displayed on the ARCodes and GeckoCodes pages when cheats are
+// disabled globally to explain why turning cheats on does not work.
+// Also displays a different warning when the game is currently running to explain
+// that toggling codes has no effect while the game is already running.
+class CheatWarningMessage final : public wxPanel
+{
+public:
+  CheatWarningMessage(wxWindow* parent, std::string game_id)
+      : wxPanel(parent), m_game_id(std::move(game_id))
+  {
+    SetExtraStyle(GetExtraStyle() | wxWS_EX_BLOCK_EVENTS);
+    CreateGUI();
+    wxTheApp->Bind(wxEVT_IDLE, &CheatWarningMessage::OnAppIdle, this);
+    Hide();
+  }
+
+  void UpdateState()
+  {
+    // If cheats are disabled then show the notification about that.
+    // If cheats are enabled and the game is currently running then display that warning.
+    State new_state = State::Hidden;
+    if (!SConfig::GetInstance().bEnableCheats)
+      new_state = State::DisabledCheats;
+    else if (Core::IsRunning() && SConfig::GetInstance().GetUniqueID() == m_game_id)
+      new_state = State::GameRunning;
+    ApplyState(new_state);
+  }
+
+private:
+  enum class State
+  {
+    Inactive,
+    Hidden,
+    DisabledCheats,
+    GameRunning
+  };
+
+  void CreateGUI()
+  {
+    wxStaticBitmap* icon =
+        new wxStaticBitmap(this, wxID_ANY, wxArtProvider::GetMessageBoxIcon(wxICON_WARNING));
+    m_message = new wxStaticText(this, wxID_ANY, wxEmptyString, wxDefaultPosition, wxDefaultSize,
+                                 wxST_NO_AUTORESIZE);
+    m_btn_configure = new wxButton(this, wxID_ANY, _("Configure Dolphin"));
+
+    m_btn_configure->Bind(wxEVT_BUTTON, &CheatWarningMessage::OnConfigureClicked, this);
+
+    wxBoxSizer* sizer = new wxBoxSizer(wxHORIZONTAL);
+    sizer->Add(icon, 0, wxALIGN_CENTER_VERTICAL | wxLEFT, 15);
+    sizer->Add(m_message, 1, wxALIGN_CENTER_VERTICAL | wxLEFT, 15);
+    sizer->Add(m_btn_configure, 0, wxALIGN_CENTER_VERTICAL | wxLEFT, 10);
+    sizer->AddSpacer(10);
+
+    SetSizer(sizer);
+  }
+
+  void OnConfigureClicked(wxCommandEvent&)
+  {
+    main_frame->OpenGeneralConfiguration();
+    UpdateState();
+  }
+
+  void OnAppIdle(wxIdleEvent& ev)
+  {
+    ev.Skip();
+    // Only respond to setting changes if we've been triggered once already.
+    if (m_state != State::Inactive)
+      UpdateState();
+  }
+
+  void ApplyState(State new_state)
+  {
+    // The purpose of this function is to prevent unnecessary UI updates which cause flickering.
+    if (new_state == m_state || (m_state == State::Inactive && new_state == State::Hidden))
+      return;
+
+    bool visible = true;
+    switch (new_state)
+    {
+    case State::Inactive:
+    case State::Hidden:
+      visible = false;
+      break;
+
+    case State::DisabledCheats:
+      m_btn_configure->Show();
+      m_message->SetLabelText(_("Dolphin's cheat system is currently disabled."));
+      break;
+
+    case State::GameRunning:
+      m_btn_configure->Hide();
+      m_message->SetLabelText(
+          _("Changing cheats will only take effect when the game is restarted."));
+      break;
+    }
+    m_state = new_state;
+    Show(visible);
+    GetParent()->Layout();
+    if (visible)
+    {
+      m_message->Wrap(m_message->GetSize().GetWidth());
+      m_message->InvalidateBestSize();
+      GetParent()->Layout();
+    }
+  }
+
+  std::string m_game_id;
+  wxStaticText* m_message = nullptr;
+  wxButton* m_btn_configure = nullptr;
+  State m_state = State::Inactive;
+};
+
 BEGIN_EVENT_TABLE(CISOProperties, wxDialog)
 EVT_CLOSE(CISOProperties::OnClose)
 EVT_BUTTON(wxID_OK, CISOProperties::OnCloseClick)
@@ -313,8 +429,8 @@ void CISOProperties::CreateGUIControls()
   m_Notebook->AddPage(m_PatchPage, _("Patches"));
   wxPanel* const m_CheatPage = new wxPanel(m_Notebook, ID_ARCODE_PAGE);
   m_Notebook->AddPage(m_CheatPage, _("AR Codes"));
-  m_geckocode_panel = new Gecko::CodeConfigPanel(m_Notebook);
-  m_Notebook->AddPage(m_geckocode_panel, _("Gecko Codes"));
+  wxPanel* const gecko_cheat_page = new wxPanel(m_Notebook);
+  m_Notebook->AddPage(gecko_cheat_page, _("Gecko Codes"));
   wxPanel* const m_Information = new wxPanel(m_Notebook, ID_INFORMATION);
   m_Notebook->AddPage(m_Information, _("Info"));
 
@@ -472,12 +588,27 @@ void CISOProperties::CreateGUIControls()
   // Action Replay Cheats
   m_ar_code_panel =
       new ActionReplayCodesPanel(m_CheatPage, ActionReplayCodesPanel::STYLE_MODIFY_BUTTONS);
+  m_cheats_disabled_ar = new CheatWarningMessage(m_CheatPage, game_id);
+
+  m_ar_code_panel->Bind(DOLPHIN_EVT_ARCODE_TOGGLED, &CISOProperties::OnCheatCodeToggled, this);
 
   wxBoxSizer* const sCheatPage = new wxBoxSizer(wxVERTICAL);
-  // TODO: Cheat disabled warning.
+  sCheatPage->Add(m_cheats_disabled_ar, 0, wxEXPAND | wxTOP, 5);
   sCheatPage->Add(m_ar_code_panel, 1, wxEXPAND | wxALL, 5);
   m_CheatPage->SetSizer(sCheatPage);
 
+  // Gecko Cheats
+  m_geckocode_panel = new Gecko::CodeConfigPanel(gecko_cheat_page);
+  m_cheats_disabled_gecko = new CheatWarningMessage(gecko_cheat_page, game_id);
+
+  m_geckocode_panel->Bind(DOLPHIN_EVT_GECKOCODE_TOGGLED, &CISOProperties::OnCheatCodeToggled, this);
+
+  wxBoxSizer* gecko_layout = new wxBoxSizer(wxVERTICAL);
+  gecko_layout->Add(m_cheats_disabled_gecko, 0, wxEXPAND | wxTOP, 5);
+  gecko_layout->Add(m_geckocode_panel, 1, wxEXPAND);
+  gecko_cheat_page->SetSizer(gecko_layout);
+
+  // Info Page
   wxStaticText* const m_InternalNameText =
       new wxStaticText(m_Information, wxID_ANY, _("Internal Name:"));
   m_InternalName = new wxTextCtrl(m_Information, ID_NAME, wxEmptyString, wxDefaultPosition,
@@ -1285,6 +1416,12 @@ void CISOProperties::OnEditConfig(wxCommandEvent& WXUNUSED(event))
   GenerateLocalIniModified();
 }
 
+void CISOProperties::OnCheatCodeToggled(wxCommandEvent&)
+{
+  m_cheats_disabled_ar->UpdateState();
+  m_cheats_disabled_gecko->UpdateState();
+}
+
 void CISOProperties::OnComputeMD5Sum(wxCommandEvent& WXUNUSED(event))
 {
   wxProgressDialog progressDialog(_("Computing MD5 checksum"), _("Working..."), 100, this,
diff --git a/Source/Core/DolphinWX/ISOProperties.h b/Source/Core/DolphinWX/ISOProperties.h
index 125ff29967..c3e70e62dd 100644
--- a/Source/Core/DolphinWX/ISOProperties.h
+++ b/Source/Core/DolphinWX/ISOProperties.h
@@ -19,7 +19,6 @@
 #include "DolphinWX/ISOFile.h"
 #include "DolphinWX/PatchAddEdit.h"
 
-class GameListItem;
 class wxButton;
 class wxCheckBox;
 class wxCheckListBox;
@@ -39,6 +38,8 @@ namespace Gecko
 class CodeConfigPanel;
 }
 class ActionReplayCodesPanel;
+class CheatWarningMessage;
+class GameListItem;
 
 class WiiPartition final : public wxTreeItemData
 {
@@ -123,6 +124,9 @@ private:
   ActionReplayCodesPanel* m_ar_code_panel;
   Gecko::CodeConfigPanel* m_geckocode_panel;
 
+  CheatWarningMessage* m_cheats_disabled_ar;
+  CheatWarningMessage* m_cheats_disabled_gecko;
+
   enum
   {
     ID_TREECTRL = 1000,
@@ -203,6 +207,7 @@ private:
   void CheckPartitionIntegrity(wxCommandEvent& event);
   void OnEmustateChanged(wxCommandEvent& event);
   void OnChangeBannerLang(wxCommandEvent& event);
+  void OnCheatCodeToggled(wxCommandEvent& event);
 
   const GameListItem OpenGameListItem;