diff --git a/Source/Core/VideoBackends/Vulkan/ObjectCache.cpp b/Source/Core/VideoBackends/Vulkan/ObjectCache.cpp
index 21459e8a8a..e484c27dac 100644
--- a/Source/Core/VideoBackends/Vulkan/ObjectCache.cpp
+++ b/Source/Core/VideoBackends/Vulkan/ObjectCache.cpp
@@ -72,6 +72,14 @@ bool ObjectCache::Initialize()
   return true;
 }
 
+static bool IsStripPrimitiveTopology(VkPrimitiveTopology topology)
+{
+  return topology == VK_PRIMITIVE_TOPOLOGY_LINE_STRIP ||
+         topology == VK_PRIMITIVE_TOPOLOGY_TRIANGLE_STRIP ||
+         topology == VK_PRIMITIVE_TOPOLOGY_LINE_STRIP_WITH_ADJACENCY ||
+         topology == VK_PRIMITIVE_TOPOLOGY_TRIANGLE_STRIP_WITH_ADJACENCY;
+}
+
 static VkPipelineRasterizationStateCreateInfo
 GetVulkanRasterizationState(const RasterizationState& state)
 {
@@ -185,9 +193,20 @@ VkPipeline ObjectCache::CreatePipeline(const PipelineInfo& info)
       nullptr,                  // const void*                                pNext
       0,                        // VkPipelineInputAssemblyStateCreateFlags    flags
       info.primitive_topology,  // VkPrimitiveTopology                        topology
-      VK_TRUE                   // VkBool32                                   primitiveRestartEnable
+      VK_FALSE                  // VkBool32                                   primitiveRestartEnable
   };
 
+  // See Vulkan spec, section 19:
+  // If topology is VK_PRIMITIVE_TOPOLOGY_POINT_LIST, VK_PRIMITIVE_TOPOLOGY_LINE_LIST,
+  // VK_PRIMITIVE_TOPOLOGY_TRIANGLE_LIST, VK_PRIMITIVE_TOPOLOGY_LINE_LIST_WITH_ADJACENCY,
+  // VK_PRIMITIVE_TOPOLOGY_TRIANGLE_LIST_WITH_ADJACENCY or VK_PRIMITIVE_TOPOLOGY_PATCH_LIST,
+  // primitiveRestartEnable must be VK_FALSE
+  if (g_ActiveConfig.backend_info.bSupportsPrimitiveRestart &&
+      IsStripPrimitiveTopology(info.primitive_topology))
+  {
+    input_assembly_state.primitiveRestartEnable = VK_TRUE;
+  }
+
   // Shaders to stages
   VkPipelineShaderStageCreateInfo shader_stages[3];
   uint32_t num_shader_stages = 0;
diff --git a/Source/Core/VideoBackends/Vulkan/VertexManager.cpp b/Source/Core/VideoBackends/Vulkan/VertexManager.cpp
index 9a5e821e19..a1d72f3011 100644
--- a/Source/Core/VideoBackends/Vulkan/VertexManager.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VertexManager.cpp
@@ -153,7 +153,10 @@ void VertexManager::vFlush()
     break;
 
   case PRIMITIVE_TRIANGLES:
-    StateTracker::GetInstance()->SetPrimitiveTopology(VK_PRIMITIVE_TOPOLOGY_TRIANGLE_STRIP);
+    StateTracker::GetInstance()->SetPrimitiveTopology(
+        g_ActiveConfig.backend_info.bSupportsPrimitiveRestart ?
+            VK_PRIMITIVE_TOPOLOGY_TRIANGLE_STRIP :
+            VK_PRIMITIVE_TOPOLOGY_TRIANGLE_LIST);
     g_renderer->SetGenerationMode();
     break;
   }
diff --git a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
index a7d1b628fb..7dc809e6b2 100644
--- a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
@@ -276,6 +276,11 @@ void VulkanContext::PopulateBackendInfoFeatures(VideoConfig* config, VkPhysicalD
   // Depth clamping implies shaderClipDistance and depthClamp
   config->backend_info.bSupportsDepthClamp =
       (features.depthClamp == VK_TRUE && features.shaderClipDistance == VK_TRUE);
+
+  // Our usage of primitive restart appears to be broken on AMD's binary drivers.
+  // Seems to be fine on GCN Gen 1-2, unconfirmed on GCN Gen 3, causes driver resets on GCN Gen 4.
+  if (DriverDetails::HasBug(DriverDetails::BUG_PRIMITIVE_RESTART))
+    config->backend_info.bSupportsPrimitiveRestart = false;
 }
 
 void VulkanContext::PopulateBackendInfoMultisampleModes(
diff --git a/Source/Core/VideoCommon/DriverDetails.cpp b/Source/Core/VideoCommon/DriverDetails.cpp
index 8d3c4715fb..072f7b69de 100644
--- a/Source/Core/VideoCommon/DriverDetails.cpp
+++ b/Source/Core/VideoCommon/DriverDetails.cpp
@@ -90,6 +90,8 @@ static BugInfo m_known_bugs[] = {
      BUG_BROKEN_DUAL_SOURCE_BLENDING, -1.0, -1.0, true},
     {API_OPENGL, OS_OSX, VENDOR_INTEL, DRIVER_INTEL, Family::UNKNOWN,
      BUG_BROKEN_DUAL_SOURCE_BLENDING, -1.0, -1.0, true},
+    {API_VULKAN, OS_ALL, VENDOR_ATI, DRIVER_ATI, Family::UNKNOWN, BUG_PRIMITIVE_RESTART, -1.0, -1.0,
+     true},
 };
 
 static std::map<Bug, BugInfo> m_bugs;