diff --git a/Source/Core/DolphinQt2/Config/Graphics/EnhancementsWidget.cpp b/Source/Core/DolphinQt2/Config/Graphics/EnhancementsWidget.cpp
index d15e910c10..d5f2927208 100644
--- a/Source/Core/DolphinQt2/Config/Graphics/EnhancementsWidget.cpp
+++ b/Source/Core/DolphinQt2/Config/Graphics/EnhancementsWidget.cpp
@@ -349,12 +349,12 @@ void EnhancementsWidget::AddDescriptions()
                  "some games as \"deflickering\" or \"smoothing\". Disabling the filter has no "
                  "effect on performance, but may result in a sharper image, and causes few "
                  "graphical issues.\n\nIf unsure, leave this checked.");
-  static const char TR_ARBITRARY_MIPMAP_DETECTION_DESCRIPTION[] =
-      QT_TR_NOOP("Enables detection of arbitrary mipmaps, which some games use for special "
-                 "distance-based effects.\nMay have false positives that result in blurry textures "
-                 "at increased internal resolution, such as in games that use very low resolution "
-                 "mipmaps.\nDisabling this can also reduce stutter in games that "
-                 "frequently load new textures.\n\nIf unsure, leave this checked.");
+  static const char TR_ARBITRARY_MIPMAP_DETECTION_DESCRIPTION[] = QT_TR_NOOP(
+      "Enables detection of arbitrary mipmaps, which some games use for special distance-based "
+      "effects. May have false positives that result in blurry textures at increased internal "
+      "resolution, such as in games that use very low resolution mipmaps.\nDisabling this can also "
+      "reduce stutter in games that frequently load new textures.\nThis feature is not compatible "
+      "with GPU Texture Decoding.\n\nIf unsure, leave this checked.");
 
   AddDescription(m_ir_combo, TR_INTERNAL_RESOLUTION_DESCRIPTION);
   AddDescription(m_aa_combo, TR_ANTIALIAS_DESCRIPTION);
diff --git a/Source/Core/VideoCommon/TextureCacheBase.cpp b/Source/Core/VideoCommon/TextureCacheBase.cpp
index 4a8807954e..8881ad2457 100644
--- a/Source/Core/VideoCommon/TextureCacheBase.cpp
+++ b/Source/Core/VideoCommon/TextureCacheBase.cpp
@@ -126,7 +126,8 @@ void TextureCacheBase::OnConfigChanged(VideoConfig& config)
       config.bTexFmtOverlayCenter != backup_config.texfmt_overlay_center ||
       config.bHiresTextures != backup_config.hires_textures ||
       config.bEnableGPUTextureDecoding != backup_config.gpu_texture_decoding ||
-      config.bDisableCopyToVRAM != backup_config.disable_vram_copies)
+      config.bDisableCopyToVRAM != backup_config.disable_vram_copies ||
+      config.bArbitraryMipmapDetection != backup_config.arbitrary_mipmap_detection)
   {
     Invalidate();
 
@@ -230,6 +231,7 @@ void TextureCacheBase::SetBackupConfig(const VideoConfig& config)
   backup_config.efb_mono_depth = config.bStereoEFBMonoDepth;
   backup_config.gpu_texture_decoding = config.bEnableGPUTextureDecoding;
   backup_config.disable_vram_copies = config.bDisableCopyToVRAM;
+  backup_config.arbitrary_mipmap_detection = config.bArbitraryMipmapDetection;
 }
 
 TextureCacheBase::TCacheEntry*
diff --git a/Source/Core/VideoCommon/TextureCacheBase.h b/Source/Core/VideoCommon/TextureCacheBase.h
index c4a17efc88..1c84662065 100644
--- a/Source/Core/VideoCommon/TextureCacheBase.h
+++ b/Source/Core/VideoCommon/TextureCacheBase.h
@@ -357,6 +357,7 @@ private:
     bool efb_mono_depth;
     bool gpu_texture_decoding;
     bool disable_vram_copies;
+    bool arbitrary_mipmap_detection;
   };
   BackupConfig backup_config = {};
 };