diff --git a/Source/Plugins/Plugin_VideoDX11/Src/Render.cpp b/Source/Plugins/Plugin_VideoDX11/Src/Render.cpp
index 5f923c6594..1fd7f095ed 100644
--- a/Source/Plugins/Plugin_VideoDX11/Src/Render.cpp
+++ b/Source/Plugins/Plugin_VideoDX11/Src/Render.cpp
@@ -950,6 +950,11 @@ void Renderer::Swap(u32 xfbAddr, FieldType field, u32 fbWidth, u32 fbHeight,cons
 	DLCache::ProgressiveCleanup();
 	TextureCache::Cleanup();
 
+	// reload textures if these settings changed
+	if (g_Config.bSafeTextureCache != g_ActiveConfig.bSafeTextureCache ||
+		g_Config.bUseNativeMips != g_ActiveConfig.bUseNativeMips)
+		TextureCache::Invalidate(false);
+
 	// Enable any configuration changes
 	UpdateActiveConfig();
 	const bool WindowResized = CheckForResize();
diff --git a/Source/Plugins/Plugin_VideoDX9/Src/Render.cpp b/Source/Plugins/Plugin_VideoDX9/Src/Render.cpp
index fe7e1d389d..dff22bb627 100644
--- a/Source/Plugins/Plugin_VideoDX9/Src/Render.cpp
+++ b/Source/Plugins/Plugin_VideoDX9/Src/Render.cpp
@@ -870,7 +870,7 @@ void Renderer::SetBlendMode(bool forceUpdate)
 {
 	if (bpmem.blendmode.logicopenable && !forceUpdate)
 		return;
-	
+
 	if (bpmem.blendmode.subtract && bpmem.blendmode.blendenable)
 	{
 		D3D::SetRenderState(D3DRS_ALPHABLENDENABLE, true);
@@ -1159,6 +1159,11 @@ void Renderer::Swap(u32 xfbAddr, FieldType field, u32 fbWidth, u32 fbHeight,cons
 	DLCache::ProgressiveCleanup();
 	TextureCache::Cleanup();
 
+	// reload textures if these settings changed
+	if (g_Config.bSafeTextureCache != g_ActiveConfig.bSafeTextureCache ||
+		g_Config.bUseNativeMips != g_ActiveConfig.bUseNativeMips)
+		TextureCache::Invalidate(false);
+
 	// Enable any configuration changes
 	UpdateActiveConfig();
 	const bool WindowResized = CheckForResize();
diff --git a/Source/Plugins/Plugin_VideoOGL/Src/Render.cpp b/Source/Plugins/Plugin_VideoOGL/Src/Render.cpp
index 1fb540ba5c..3b1cf8b883 100644
--- a/Source/Plugins/Plugin_VideoOGL/Src/Render.cpp
+++ b/Source/Plugins/Plugin_VideoOGL/Src/Render.cpp
@@ -1350,11 +1350,16 @@ void Renderer::Swap(u32 xfbAddr, FieldType field, u32 fbWidth, u32 fbHeight,cons
 	GL_REPORT_ERRORD();
 	g_Config.iSaveTargetId = 0;
 
-	bool last_copy_efb_to_Texture = g_ActiveConfig.bCopyEFBToTexture;
-	UpdateActiveConfig();
-	if (last_copy_efb_to_Texture != g_ActiveConfig.bCopyEFBToTexture)
+	// reload textures if these settings changed
+	if (g_Config.bSafeTextureCache != g_ActiveConfig.bSafeTextureCache ||
+		g_Config.bUseNativeMips != g_ActiveConfig.bUseNativeMips)
+		TextureCache::Invalidate(false);
+
+	if (g_Config.bCopyEFBToTexture != g_ActiveConfig.bCopyEFBToTexture)
 		TextureCache::ClearRenderTargets();
 
+	UpdateActiveConfig();
+
 	// For testing zbuffer targets.
 	// Renderer::SetZBufferRender();
 	// SaveTexture("tex.tga", GL_TEXTURE_RECTANGLE_ARB, s_FakeZTarget,