diff --git a/Source/Core/Core/PowerPC/JitArm64/JitArm64_LoadStore.cpp b/Source/Core/Core/PowerPC/JitArm64/JitArm64_LoadStore.cpp
index be39929f21..12c0bfe26c 100644
--- a/Source/Core/Core/PowerPC/JitArm64/JitArm64_LoadStore.cpp
+++ b/Source/Core/Core/PowerPC/JitArm64/JitArm64_LoadStore.cpp
@@ -141,8 +141,12 @@ void JitArm64::SafeLoadToReg(u32 dest, s32 addr, s32 offsetReg, u32 flags, s32 o
   }
   else if (mmio_address)
   {
+    regs_in_use[DecodeReg(ARM64Reg::W0)] = 0;
+    regs_in_use[DecodeReg(ARM64Reg::W30)] = 0;
+    regs_in_use[DecodeReg(dest_reg)] = 0;
     MMIOLoadToReg(Memory::mmio_mapping.get(), this, &m_float_emit, regs_in_use, fprs_in_use,
                   dest_reg, mmio_address, flags);
+    addr_reg_set = false;
   }
   else
   {
@@ -308,8 +312,13 @@ void JitArm64::SafeStoreFromReg(s32 dest, u32 value, s32 regOffset, u32 flags, s
   }
   else if (mmio_address)
   {
+    regs_in_use[DecodeReg(ARM64Reg::W0)] = 0;
+    regs_in_use[DecodeReg(ARM64Reg::W1)] = 0;
+    regs_in_use[DecodeReg(ARM64Reg::W30)] = 0;
+    regs_in_use[DecodeReg(RS)] = 0;
     MMIOWriteRegToAddr(Memory::mmio_mapping.get(), this, &m_float_emit, regs_in_use, fprs_in_use,
                        RS, mmio_address, flags);
+    addr_reg_set = false;
   }
   else
   {