diff --git a/Source/Core/DolphinWX/Main.cpp b/Source/Core/DolphinWX/Main.cpp
index 305cae3b7d..9eef4b3d0c 100644
--- a/Source/Core/DolphinWX/Main.cpp
+++ b/Source/Core/DolphinWX/Main.cpp
@@ -82,6 +82,8 @@ std::string wxStringTranslator(const char*);
 
 CFrame* main_frame = nullptr;
 
+static std::mutex s_init_mutex;
+
 bool DolphinApp::Initialize(int& c, wxChar** v)
 {
 #if defined HAVE_X11 && HAVE_X11
@@ -94,6 +96,7 @@ bool DolphinApp::Initialize(int& c, wxChar** v)
 
 bool DolphinApp::OnInit()
 {
+  std::lock_guard<std::mutex> lk(s_init_mutex);
   if (!wxApp::OnInit())
     return false;
 
@@ -548,6 +551,7 @@ bool Host_RendererIsFullscreen()
 
 void Host_ConnectWiimote(int wm_idx, bool connect)
 {
+  std::lock_guard<std::mutex> lk(s_init_mutex);
   if (connect)
   {
     wxCommandEvent event(wxEVT_HOST_COMMAND, IDM_FORCE_CONNECT_WIIMOTE1 + wm_idx);