diff --git a/data/strings/en.ini b/data/strings/en.ini
index 6a49f0807..fded586fa 100644
--- a/data/strings/en.ini
+++ b/data/strings/en.ini
@@ -1282,6 +1282,7 @@ download_themes = Download Themes
 open_theme_folder = Open &Folder
 language_extensions = Languages
 theme_extensions = Themes
+keys_extensions = Keyboard Shortcuts
 script_extensions = Scripts
 palette_extensions = Palettes
 dithering_matrix_extensions = Dithering Matrices
diff --git a/src/app/app_menus.cpp b/src/app/app_menus.cpp
index c2418d849..65f04a8a2 100644
--- a/src/app/app_menus.cpp
+++ b/src/app/app_menus.cpp
@@ -1,5 +1,5 @@
 // Aseprite
-// Copyright (C) 2019-2020  Igara Studio S.A.
+// Copyright (C) 2019-2022  Igara Studio S.A.
 // Copyright (C) 2001-2018  David Capello
 //
 // This program is distributed under the terms of
@@ -16,6 +16,7 @@
 #include "app/commands/commands.h"
 #include "app/commands/params.h"
 #include "app/console.h"
+#include "app/extensions.h"
 #include "app/gui_xml.h"
 #include "app/i18n/strings.h"
 #include "app/recent_files.h"
@@ -417,10 +418,22 @@ void AppMenus::reload()
     .FirstChild("gui")
     .FirstChild("keyboard").ToElement();
 
+  // From a fresh start, load the default keys
   KeyboardShortcuts::instance()->clear();
   KeyboardShortcuts::instance()->importFile(xmlKey, KeySource::Original);
 
-  // Load user settings
+  // Load extension-defined keys
+  for (const Extension* ext : App::instance()->extensions()) {
+    if (ext->isEnabled() &&
+        ext->hasKeys()) {
+      for (const auto& kv : ext->keys()) {
+        KeyboardShortcuts::instance()->importFile(
+          kv.second, KeySource::ExtensionDefined);
+      }
+    }
+  }
+
+  // Load user-defined keys
   {
     ResourceFinder rf;
     rf.includeUserDir("user.aseprite-keys");
diff --git a/src/app/commands/cmd_keyboard_shortcuts.cpp b/src/app/commands/cmd_keyboard_shortcuts.cpp
index 120c54825..d544b80bc 100644
--- a/src/app/commands/cmd_keyboard_shortcuts.cpp
+++ b/src/app/commands/cmd_keyboard_shortcuts.cpp
@@ -58,7 +58,7 @@ using namespace ui;
 
 namespace {
 
-typedef std::map<AppMenuItem*, KeyPtr> MenuKeys;
+using MenuKeys = std::map<AppMenuItem*, KeyPtr>;
 
 class HeaderSplitter : public Splitter {
 public:
@@ -195,7 +195,7 @@ private:
     window.openWindowInForeground();
 
     if (window.isModified()) {
-      m_key->disableAccel(origAccel);
+      m_key->disableAccel(origAccel, KeySource::UserDefined);
       if (!window.accel().isEmpty())
         m_key->add(window.accel(), KeySource::UserDefined, m_keys);
     }
@@ -215,7 +215,7 @@ private:
             accel.toString())) != 1)
       return;
 
-    m_key->disableAccel(accel);
+    m_key->disableAccel(accel, KeySource::UserDefined);
     window()->layout();
   }
 
diff --git a/src/app/commands/cmd_options.cpp b/src/app/commands/cmd_options.cpp
index 99c13b969..80f0ce451 100644
--- a/src/app/commands/cmd_options.cpp
+++ b/src/app/commands/cmd_options.cpp
@@ -1277,6 +1277,10 @@ private:
     if (extensionsList()->getItemsCount() > 0)
       return;
 
+    loadExtensionsByCategory(
+      Extension::Category::Keys,
+      Strings::options_keys_extensions());
+
     loadExtensionsByCategory(
       Extension::Category::Languages,
       Strings::options_language_extensions());
diff --git a/src/app/extensions.cpp b/src/app/extensions.cpp
index cde81cd99..e97febdcd 100644
--- a/src/app/extensions.cpp
+++ b/src/app/extensions.cpp
@@ -257,6 +257,12 @@ void Extension::executeExitActions()
 #endif // ENABLE_SCRIPTING
 }
 
+void Extension::addKeys(const std::string& id, const std::string& path)
+{
+  m_keys[id] = path;
+  updateCategory(Category::Keys);
+}
+
 void Extension::addLanguage(const std::string& id, const std::string& path)
 {
   m_languages[id] = path;
@@ -456,8 +462,10 @@ bool Extension::isDefaultTheme() const
 
 void Extension::updateCategory(const Category newCategory)
 {
-  if (m_category == Category::None)
+  if (m_category == Category::None ||
+      m_category == Category::Keys) {
     m_category = newCategory;
+  }
   else if (m_category != newCategory)
     m_category = Category::Multiple;
 }
@@ -1016,6 +1024,24 @@ Extension* Extensions::loadExtension(const std::string& path,
 
   auto contributes = json["contributes"];
   if (contributes.is_object()) {
+    // Keys
+    auto keys = contributes["keys"];
+    if (keys.is_array()) {
+      for (const auto& key : keys.array_items()) {
+        std::string keyId = key["id"].string_value();
+        std::string keyPath = key["path"].string_value();
+
+        // The path must be always relative to the extension
+        keyPath = base::join_path(path, keyPath);
+
+        LOG("EXT: New keyboard shortcuts '%s' in '%s'\n",
+            keyId.c_str(),
+            keyPath.c_str());
+
+        extension->addKeys(keyId, keyPath);
+      }
+    }
+
     // Languages
     auto languages = contributes["languages"];
     if (languages.is_array()) {
@@ -1130,6 +1156,7 @@ Extension* Extensions::loadExtension(const std::string& path,
 
 void Extensions::generateExtensionSignals(Extension* extension)
 {
+  if (extension->hasKeys()) KeysChange(extension);
   if (extension->hasLanguages()) LanguagesChange(extension);
   if (extension->hasThemes()) ThemesChange(extension);
   if (extension->hasPalettes()) PalettesChange(extension);
diff --git a/src/app/extensions.h b/src/app/extensions.h
index ab2e7492b..00b222d27 100644
--- a/src/app/extensions.h
+++ b/src/app/extensions.h
@@ -1,5 +1,5 @@
 // Aseprite
-// Copyright (C) 2020  Igara Studio S.A.
+// Copyright (C) 2020-2022  Igara Studio S.A.
 // Copyright (C) 2017-2018  David Capello
 //
 // This program is distributed under the terms of
@@ -36,6 +36,7 @@ namespace app {
   public:
     enum class Category {
       None,
+      Keys,
       Languages,
       Themes,
       Scripts,
@@ -78,10 +79,12 @@ namespace app {
     const std::string& displayName() const { return m_displayName; }
     const Category category() const { return m_category; }
 
+    const ExtensionItems& keys() const { return m_keys; }
     const ExtensionItems& languages() const { return m_languages; }
     const ExtensionItems& themes() const { return m_themes; }
     const ExtensionItems& palettes() const { return m_palettes; }
 
+    void addKeys(const std::string& id, const std::string& path);
     void addLanguage(const std::string& id, const std::string& path);
     void addTheme(const std::string& id, const std::string& path);
     void addPalette(const std::string& id, const std::string& path);
@@ -98,6 +101,7 @@ namespace app {
     bool canBeDisabled() const;
     bool canBeUninstalled() const;
 
+    bool hasKeys() const { return !m_keys.empty(); }
     bool hasLanguages() const { return !m_languages.empty(); }
     bool hasThemes() const { return !m_themes.empty(); }
     bool hasPalettes() const { return !m_palettes.empty(); }
@@ -119,6 +123,7 @@ namespace app {
     void exitScripts();
 #endif
 
+    ExtensionItems m_keys;
     ExtensionItems m_languages;
     ExtensionItems m_themes;
     ExtensionItems m_palettes;
@@ -180,6 +185,7 @@ namespace app {
     std::vector<Extension::DitheringMatrixInfo> ditheringMatrices();
 
     obs::signal<void(Extension*)> NewExtension;
+    obs::signal<void(Extension*)> KeysChange;
     obs::signal<void(Extension*)> LanguagesChange;
     obs::signal<void(Extension*)> ThemesChange;
     obs::signal<void(Extension*)> PalettesChange;
diff --git a/src/app/ui/key.h b/src/app/ui/key.h
index 7ff1f41ec..923193808 100644
--- a/src/app/ui/key.h
+++ b/src/app/ui/key.h
@@ -1,5 +1,5 @@
 // Aseprite
-// Copyright (C) 2018  Igara Studio S.A.
+// Copyright (C) 2018-2022  Igara Studio S.A.
 // Copyright (C) 2001-2018  David Capello
 //
 // This program is distributed under the terms of
@@ -15,6 +15,7 @@
 #include "ui/accelerator.h"
 
 #include <memory>
+#include <utility>
 #include <vector>
 
 namespace ui {
@@ -31,6 +32,7 @@ namespace app {
 
   enum class KeySource {
     Original,
+    ExtensionDefined,
     UserDefined
   };
 
@@ -98,20 +100,20 @@ namespace app {
     return KeyAction(int(a) & int(b));
   }
 
+  using KeySourceAccelList = std::vector<std::pair<KeySource, ui::Accelerator>>;
+
   class Key {
   public:
+    Key(const Key& key);
     Key(Command* command, const Params& params, KeyContext keyContext);
     Key(KeyType type, tools::Tool* tool);
     explicit Key(KeyAction action);
     explicit Key(WheelAction action);
 
     KeyType type() const { return m_type; }
-    const ui::Accelerators& accels() const {
-      return (m_useUsers ? m_users: m_accels);
-    }
-    const ui::Accelerators& origAccels() const { return m_accels; }
-    const ui::Accelerators& userAccels() const { return m_users; }
-    const ui::Accelerators& userRemovedAccels() const { return m_userRemoved; }
+    const ui::Accelerators& accels() const;
+    const KeySourceAccelList addsKeys() const { return m_adds; }
+    const KeySourceAccelList delsKeys() const { return m_dels; }
 
     void add(const ui::Accelerator& accel,
              const KeySource source,
@@ -122,9 +124,15 @@ namespace app {
     bool isLooselyPressed() const;
 
     bool hasAccel(const ui::Accelerator& accel) const;
-    void disableAccel(const ui::Accelerator& accel);
+    bool hasUserDefinedAccels() const;
 
-    // Resets user accelerators to the original ones.
+    // The KeySource indicates from where the key was disabled
+    // (e.g. if it was removed from an extension-defined file, or from
+    // user-defined).
+    void disableAccel(const ui::Accelerator& accel,
+                      const KeySource source);
+
+    // Resets user accelerators to the original & extension-defined ones.
     void reset();
 
     void copyOriginalToUser();
@@ -144,10 +152,11 @@ namespace app {
 
   private:
     KeyType m_type;
-    ui::Accelerators m_accels;      // Default accelerators (from gui.xml)
-    ui::Accelerators m_users;       // User-defined accelerators
-    ui::Accelerators m_userRemoved; // Default accelerators removed by user
-    bool m_useUsers;
+    KeySourceAccelList m_adds;
+    KeySourceAccelList m_dels;
+    // Final list of accelerators after processing the
+    // addition/deletion of extension-defined & user-defined keys.
+    mutable std::unique_ptr<ui::Accelerators> m_accels;
     KeyContext m_keycontext;
 
     // for KeyType::Command
@@ -161,8 +170,8 @@ namespace app {
     WheelAction m_wheelAction;
   };
 
-  typedef std::shared_ptr<Key> KeyPtr;
-  typedef std::vector<KeyPtr> Keys;
+  using KeyPtr = std::shared_ptr<Key> ;
+  using Keys = std::vector<KeyPtr>;
 
   std::string convertKeyContextToString(KeyContext keyContext);
   std::string convertKeyContextToUserFriendlyString(KeyContext keyContext);
diff --git a/src/app/ui/keyboard_shortcuts.cpp b/src/app/ui/keyboard_shortcuts.cpp
index 4803bae0f..e0d728857 100644
--- a/src/app/ui/keyboard_shortcuts.cpp
+++ b/src/app/ui/keyboard_shortcuts.cpp
@@ -1,5 +1,5 @@
 // Aseprite
-// Copyright (C) 2018-2020  Igara Studio S.A.
+// Copyright (C) 2018-2022  Igara Studio S.A.
 // Copyright (C) 2001-2018  David Capello
 //
 // This program is distributed under the terms of
@@ -124,6 +124,32 @@ namespace {
     return std::string();
   }
 
+  void erase_accel(app::KeySourceAccelList& kvs,
+                   const app::KeySource source,
+                   const ui::Accelerator& accel) {
+    for (auto it=kvs.begin(); it!=kvs.end(); ) {
+      auto& kv = *it;
+      if (kv.first == source &&
+          kv.second == accel) {
+        it = kvs.erase(it);
+      }
+      else
+        ++it;
+    }
+  }
+
+  void erase_accels(app::KeySourceAccelList& kvs,
+                    const app::KeySource source) {
+    for (auto it=kvs.begin(); it!=kvs.end(); ) {
+      auto& kv = *it;
+      if (kv.first == source) {
+        it = kvs.erase(it);
+      }
+      else
+        ++it;
+    }
+  }
+
 } // anonymous namespace
 
 namespace base {
@@ -171,9 +197,33 @@ using namespace ui;
 //////////////////////////////////////////////////////////////////////
 // Key
 
+Key::Key(const Key& k)
+  : m_type(k.m_type)
+  , m_adds(k.m_adds)
+  , m_dels(k.m_dels)
+  , m_keycontext(k.m_keycontext)
+{
+  switch (m_type) {
+    case KeyType::Command:
+      m_command = k.m_command;
+      m_params = k.m_params;
+      break;
+    case KeyType::Tool:
+    case KeyType::Quicktool:
+      m_tool = k.m_tool;
+      break;
+    case KeyType::Action:
+      m_action = k.m_action;
+      break;
+    case KeyType::WheelAction:
+      m_action = k.m_action;
+      m_wheelAction = k.m_wheelAction;
+      break;
+  }
+}
+
 Key::Key(Command* command, const Params& params, KeyContext keyContext)
   : m_type(KeyType::Command)
-  , m_useUsers(false)
   , m_keycontext(keyContext)
   , m_command(command)
   , m_params(params)
@@ -182,7 +232,6 @@ Key::Key(Command* command, const Params& params, KeyContext keyContext)
 
 Key::Key(KeyType type, tools::Tool* tool)
   : m_type(type)
-  , m_useUsers(false)
   , m_keycontext(KeyContext::Any)
   , m_tool(tool)
 {
@@ -190,7 +239,6 @@ Key::Key(KeyType type, tools::Tool* tool)
 
 Key::Key(KeyAction action)
   : m_type(KeyType::Action)
-  , m_useUsers(false)
   , m_keycontext(KeyContext::Any)
   , m_action(action)
 {
@@ -239,35 +287,63 @@ Key::Key(KeyAction action)
 
 Key::Key(WheelAction wheelAction)
   : m_type(KeyType::WheelAction)
-  , m_useUsers(false)
   , m_keycontext(KeyContext::MouseWheel)
   , m_action(KeyAction::None)
   , m_wheelAction(wheelAction)
 {
 }
 
+const ui::Accelerators& Key::accels() const
+{
+  if (!m_accels) {
+    m_accels = std::make_unique<ui::Accelerators>();
+
+    // Add default keys
+    for (const auto& kv : m_adds) {
+      if (kv.first == KeySource::Original)
+        m_accels->add(kv.second);
+    }
+
+    // Delete/add extension-defined keys
+    for (const auto& kv : m_dels) {
+      if (kv.first == KeySource::ExtensionDefined)
+        m_accels->remove(kv.second);
+      else {
+        ASSERT(kv.first != KeySource::Original);
+      }
+    }
+    for (const auto& kv : m_adds) {
+      if (kv.first == KeySource::ExtensionDefined)
+        m_accels->add(kv.second);
+    }
+
+    // Delete/add user-defined keys
+    for (const auto& kv : m_dels) {
+      if (kv.first == KeySource::UserDefined)
+        m_accels->remove(kv.second);
+    }
+    for (const auto& kv : m_adds) {
+      if (kv.first == KeySource::UserDefined)
+        m_accels->add(kv.second);
+    }
+  }
+  return *m_accels;
+}
+
 void Key::add(const ui::Accelerator& accel,
               const KeySource source,
               KeyboardShortcuts& globalKeys)
 {
-  Accelerators* accels = &m_accels;
-
-  if (source == KeySource::UserDefined) {
-    if (!m_useUsers) {
-      m_useUsers = true;
-      m_users = m_accels;
-    }
-    accels = &m_users;
-  }
+  m_adds.emplace_back(source, accel);
+  m_accels.reset();
 
   // Remove the accelerator from other commands
-  if (source == KeySource::UserDefined) {
-    globalKeys.disableAccel(accel, m_keycontext, this);
-    m_userRemoved.remove(accel);
-  }
+  if (source == KeySource::ExtensionDefined ||
+      source == KeySource::UserDefined) {
+    erase_accel(m_dels, source, accel);
 
-  // Add the accelerator
-  accels->add(accel);
+    globalKeys.disableAccel(accel, source, m_keycontext, this);
+  }
 }
 
 const ui::Accelerator* Key::isPressed(const Message* msg,
@@ -322,31 +398,47 @@ bool Key::hasAccel(const ui::Accelerator& accel) const
   return accels().has(accel);
 }
 
-void Key::disableAccel(const ui::Accelerator& accel)
+bool Key::hasUserDefinedAccels() const
 {
-  if (!m_useUsers) {
-    m_useUsers = true;
-    m_users = m_accels;
+  for (const auto& kv : m_adds) {
+    if (kv.first == KeySource::UserDefined)
+      return true;
   }
+  return false;
+}
 
-  m_users.remove(accel);
+void Key::disableAccel(const ui::Accelerator& accel,
+                       const KeySource source)
+{
+  // It doesn't make sense that the default keyboard shortcuts file
+  // (gui.xml) removes some accelerator.
+  ASSERT(source != KeySource::Original);
 
-  if (m_accels.has(accel))
-    m_userRemoved.add(accel);
+  erase_accel(m_adds, source, accel);
+  erase_accel(m_dels, source, accel);
+
+  m_dels.emplace_back(source, accel);
+  m_accels.reset();
 }
 
 void Key::reset()
 {
-  m_users.clear();
-  m_userRemoved.clear();
-  m_useUsers = false;
+  erase_accels(m_adds, KeySource::UserDefined);
+  erase_accels(m_dels, KeySource::UserDefined);
+  m_accels.reset();
 }
 
 void Key::copyOriginalToUser()
 {
-  m_users = m_accels;
-  m_userRemoved.clear();
-  m_useUsers = true;
+  // Erase all user-defined keys
+  erase_accels(m_adds, KeySource::UserDefined);
+  erase_accels(m_dels, KeySource::UserDefined);
+
+  // Then copy all original & extension-defined keys as user-defined
+  auto copy = m_adds;
+  for (const auto& kv : copy)
+    m_adds.emplace_back(KeySource::UserDefined, kv.second);
+  m_accels.reset();
 }
 
 std::string Key::triggerString() const
@@ -465,7 +557,7 @@ void KeyboardShortcuts::importFile(TiXmlElement* rootElement, KeySource source)
             }
           }
           else
-            key->disableAccel(accel);
+            key->disableAccel(accel, source);
         }
       }
     }
@@ -494,7 +586,7 @@ void KeyboardShortcuts::importFile(TiXmlElement* rootElement, KeySource source)
           if (!removed)
             key->add(accel, source, *this);
           else
-            key->disableAccel(accel);
+            key->disableAccel(accel, source);
         }
       }
     }
@@ -522,7 +614,7 @@ void KeyboardShortcuts::importFile(TiXmlElement* rootElement, KeySource source)
           if (!removed)
             key->add(accel, source, *this);
           else
-            key->disableAccel(accel);
+            key->disableAccel(accel, source);
         }
       }
     }
@@ -550,7 +642,7 @@ void KeyboardShortcuts::importFile(TiXmlElement* rootElement, KeySource source)
           if (!removed)
             key->add(accel, source, *this);
           else
-            key->disableAccel(accel);
+            key->disableAccel(accel, source);
         }
       }
     }
@@ -578,7 +670,7 @@ void KeyboardShortcuts::importFile(TiXmlElement* rootElement, KeySource source)
           if (!removed)
             key->add(accel, source, *this);
           else
-            key->disableAccel(accel);
+            key->disableAccel(accel, source);
         }
       }
     }
@@ -633,11 +725,13 @@ void KeyboardShortcuts::exportKeys(TiXmlElement& parent, KeyType type)
     if (key->type() != type)
       continue;
 
-    for (const ui::Accelerator& accel : key->userRemovedAccels())
-      exportAccel(parent, key.get(), accel, true);
+    for (const auto& kv : key->delsKeys())
+      if (kv.first == KeySource::UserDefined)
+        exportAccel(parent, key.get(), kv.second, true);
 
-    for (const ui::Accelerator& accel : key->userAccels())
-      exportAccel(parent, key.get(), accel, false);
+    for (const auto& kv : key->addsKeys())
+      if (kv.first == KeySource::UserDefined)
+        exportAccel(parent, key.get(), kv.second, false);
   }
 }
 
@@ -773,17 +867,19 @@ KeyPtr KeyboardShortcuts::wheelAction(WheelAction wheelAction)
 }
 
 void KeyboardShortcuts::disableAccel(const ui::Accelerator& accel,
+                                     const KeySource source,
                                      const KeyContext keyContext,
                                      const Key* newKey)
 {
   for (KeyPtr& key : m_keys) {
-    if (key->keycontext() == keyContext &&
+    if (key.get() != newKey &&
+        key->keycontext() == keyContext &&
         key->hasAccel(accel) &&
         // Tools can contain the same keyboard shortcut
         (key->type() != KeyType::Tool ||
          newKey == nullptr ||
          newKey->type() != KeyType::Tool)) {
-      key->disableAccel(accel);
+      key->disableAccel(accel, source);
     }
   }
 }
@@ -885,7 +981,7 @@ bool KeyboardShortcuts::hasMouseWheelCustomization() const
 {
   for (const KeyPtr& key : m_keys) {
     if (key->type() == KeyType::WheelAction &&
-        !key->userAccels().empty())
+        key->hasUserDefinedAccels())
       return true;
   }
   return false;
diff --git a/src/app/ui/keyboard_shortcuts.h b/src/app/ui/keyboard_shortcuts.h
index 2bd04a863..934fe62c2 100644
--- a/src/app/ui/keyboard_shortcuts.h
+++ b/src/app/ui/keyboard_shortcuts.h
@@ -1,4 +1,5 @@
 // Aseprite
+// Copyright (C) 2022  Igara Studio S.A.
 // Copyright (C) 2001-2018  David Capello
 //
 // This program is distributed under the terms of
@@ -50,6 +51,7 @@ namespace app {
     KeyPtr wheelAction(WheelAction action);
 
     void disableAccel(const ui::Accelerator& accel,
+                      const KeySource source,
                       const KeyContext keyContext,
                       const Key* newKey);
 
diff --git a/src/app/ui/main_menu_bar.cpp b/src/app/ui/main_menu_bar.cpp
index 8461a6dd1..6ab3cbc76 100644
--- a/src/app/ui/main_menu_bar.cpp
+++ b/src/app/ui/main_menu_bar.cpp
@@ -24,9 +24,11 @@ MainMenuBar::MainMenuBar()
 {
   Extensions& extensions = App::instance()->extensions();
 
-  m_extScripts =
-    extensions.ScriptsChange.connect(
-      [this]{ reload(); });
+  // Reload the main menu if there are changes in keyboard shortcuts
+  // or scripts when extensions are installed/uninstalled or
+  // enabled/disabled.
+  m_extKeys = extensions.KeysChange.connect( [this]{ reload(); });
+  m_extScripts = extensions.ScriptsChange.connect( [this]{ reload(); });
 }
 
 void MainMenuBar::reload()
diff --git a/src/app/ui/main_menu_bar.h b/src/app/ui/main_menu_bar.h
index ec76e5e2f..fed0da4c3 100644
--- a/src/app/ui/main_menu_bar.h
+++ b/src/app/ui/main_menu_bar.h
@@ -1,5 +1,5 @@
 // Aseprite
-// Copyright (C) 2020  Igara Studio S.A
+// Copyright (C) 2020-2022  Igara Studio S.A
 // Copyright (C) 2001-2015  David Capello
 //
 // This program is distributed under the terms of
@@ -21,6 +21,7 @@ namespace app {
     void reload();
 
   private:
+    obs::scoped_connection m_extKeys;
     obs::scoped_connection m_extScripts;
   };