diff --git a/data/strings/en.ini b/data/strings/en.ini
index ad380ddd3..9e1d54e2c 100644
--- a/data/strings/en.ini
+++ b/data/strings/en.ini
@@ -115,6 +115,8 @@ file_format_indexed_mode = Indexed mode
 file_format_layers = Layers
 file_format_palette_changes = Palette changes between frames
 file_format_rgb_mode = RGB mode
+file_format_20ms_min_duration = Frame duration less than 20ms
+file_format_10ms_duration_precision = Frame duration other than a multiple of 10ms
 invalid_chars_in_filename = <<<END
 Error
 <<The file name cannot contain the following character(s):
diff --git a/src/app/file/file.cpp b/src/app/file/file.cpp
index 7df4bea90..04e52a134 100644
--- a/src/app/file/file.cpp
+++ b/src/app/file/file.cpp
@@ -607,6 +607,22 @@ FileOp* FileOp::createSaveDocumentOperation(const Context* context,
     }
   }
 
+  // GIF doesn't support frame duration less than 20ms, also
+  // the duration of each frame will be floored to 10ms multiples.
+  if (fop->m_format->support(FILE_GIF_ANI_LIMITATIONS)) {
+    bool durationLessThan20 = false;
+    bool milisecPrecision = false;
+    for (int i=0; i<fop->document()->sprite()->totalFrames(); ++i) {
+        int frameDuration = fop->document()->sprite()->frameDuration(i);
+        if (frameDuration < 20) durationLessThan20 = true;
+        if (frameDuration % 10) milisecPrecision = true;
+    }
+    if (durationLessThan20)
+      warnings += "<<- " + Strings::alerts_file_format_20ms_min_duration();
+    if (milisecPrecision)
+      warnings += "<<- " + Strings::alerts_file_format_10ms_duration_precision();
+  }
+
   // Show the confirmation alert
   if (!warnings.empty()) {
 #ifdef ENABLE_UI
diff --git a/src/app/file/file_format.h b/src/app/file/file_format.h
index 6503d1552..a9ddbaa8d 100644
--- a/src/app/file/file_format.h
+++ b/src/app/file/file_format.h
@@ -1,5 +1,5 @@
 // Aseprite
-// Copyright (C) 2019-2022  Igara Studio S.A.
+// Copyright (C) 2019-2023  Igara Studio S.A.
 // Copyright (C) 2001-2018  David Capello
 //
 // This program is distributed under the terms of
@@ -31,6 +31,7 @@
 #define FILE_SUPPORT_BIG_PALETTES       0x00002000 // Palettes w/more than 256 colors
 #define FILE_SUPPORT_PALETTE_WITH_ALPHA 0x00004000
 #define FILE_ENCODE_ABSTRACT_IMAGE      0x00008000 // Use the new FileAbstractImage
+#define FILE_GIF_ANI_LIMITATIONS        0x00010000
 
 namespace app {
 
diff --git a/src/app/file/gif_format.cpp b/src/app/file/gif_format.cpp
index 5e568d50a..78ee43a77 100644
--- a/src/app/file/gif_format.cpp
+++ b/src/app/file/gif_format.cpp
@@ -1,5 +1,5 @@
 // Aseprite
-// Copyright (C) 2018-2022  Igara Studio S.A.
+// Copyright (C) 2018-2023  Igara Studio S.A.
 // Copyright (C) 2001-2018  David Capello
 //
 // This program is distributed under the terms of
@@ -94,7 +94,8 @@ class GifFormat : public FileFormat {
       FILE_SUPPORT_FRAMES |
       FILE_SUPPORT_PALETTES |
       FILE_SUPPORT_GET_FORMAT_OPTIONS |
-      FILE_ENCODE_ABSTRACT_IMAGE;
+      FILE_ENCODE_ABSTRACT_IMAGE |
+      FILE_GIF_ANI_LIMITATIONS;
   }
 
   bool onLoad(FileOp* fop) override;